Circulating growth hormone binding proteins

R. G. Rosenfeld

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The 'high-affinity' growth hormone binding protein (GHBP) corresponds to the extracellular domain of the membrane-associated GH receptor. In man, it is produced by proteolytic cleavage of the extracellular portion of the receptor, while in the rat and mouse, it is the product of alternative splicing of GH receptor mRNA. Because of the relationship between the GHBP and the GH receptor, measurement of serum concentrations of GHBP provide an index of GH receptor concentrations and/or affinity.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalHormone Research
Volume42
Issue number4-5
DOIs
StatePublished - Jan 1 1994

Keywords

  • Growth hormone
  • Growth hormone binding protein
  • Growth hormone insensitivity
  • Growth hormone receptor
  • Growth hormone receptor deficiency
  • Laron syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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