Circulating growth hormone binding proteins

R. G. Rosenfeld

doi:10.1159/000184184

Circulating growth hormone binding proteins

R. G. Rosenfeld

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The 'high-affinity' growth hormone binding protein (GHBP) corresponds to the extracellular domain of the membrane-associated GH receptor. In man, it is produced by proteolytic cleavage of the extracellular portion of the receptor, while in the rat and mouse, it is the product of alternative splicing of GH receptor mRNA. Because of the relationship between the GHBP and the GH receptor, measurement of serum concentrations of GHBP provide an index of GH receptor concentrations and/or affinity.

Original language	English (US)
Pages (from-to)	129-132
Number of pages	4
Journal	Hormone Research
Volume	42
Issue number	4-5
DOIs	https://doi.org/10.1159/000184184
State	Published - 1994
Externally published	Yes

Keywords

Growth hormone
Growth hormone binding protein
Growth hormone insensitivity
Growth hormone receptor
Growth hormone receptor deficiency
Laron syndrome

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1159/000184184

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AB - The 'high-affinity' growth hormone binding protein (GHBP) corresponds to the extracellular domain of the membrane-associated GH receptor. In man, it is produced by proteolytic cleavage of the extracellular portion of the receptor, while in the rat and mouse, it is the product of alternative splicing of GH receptor mRNA. Because of the relationship between the GHBP and the GH receptor, measurement of serum concentrations of GHBP provide an index of GH receptor concentrations and/or affinity.

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KW - Growth hormone binding protein

KW - Growth hormone insensitivity

KW - Growth hormone receptor

KW - Growth hormone receptor deficiency

KW - Laron syndrome

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Circulating growth hormone binding proteins

Abstract

Keywords

ASJC Scopus subject areas

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