Circulating 25-hydroxyvitamin D levels and frailty in older men: The osteoporotic fractures in men study

Kristine E. Ensrud, Terri L. Blackwell, Jane A. Cauley, Steven R. Cummings, Elizabeth Barrett-Connor, Thuy Tien L Dam, Andrew R. Hoffman, James M. Shikany, Nancy E. Lane, Marcia L. Stefanick, Eric Orwoll, Peggy M. Cawthon

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men. DESIGN: Prospective cohort study. SETTING: Six U.S. community-based centers. PARTICIPANTS: One thousand six hundred six men aged 65 and older. MEASUREMENTS: 25(OH)D (liquid chromatography tandem mass spectroscopy) and frailty status (criteria similar to those used in the Cardiovascular Health Study) measured at baseline; frailty status assessment repeated an average of 4.6 years later. Frailty status was classified as robust, intermediate, or frail at baseline and robust, intermediate, frail, or dead at follow-up. RESULTS: After adjusting for multiple potential confounders, men with 25(OH)D levels less than 20.0 ng/mL had 1.5 times higher odds (multivariate odds ratio (MOR)=1.47, 95% confidence interval (CI)=1.07-2.02) of greater frailty status at baseline than men with 25(OH)D levels of 30.0 ng/mL or greater (referent group), whereas frailty status was similar in men with 25(OH)D levels from 20.0 to 29.9 ng/mL and those with levels of 30.0 ng/mL or greater (MOR=1.02, 95% CI=0.78-1.32). However, in 1,267 men not classified as frail at baseline, there was no association between lower baseline 25(OH)D level and odds of greater frailty status at the 4.6-year follow-up. Findings were the same when 25(OH)D was expressed in quartiles or as a continuous variable. CONCLUSION: Lower levels of 25(OH)D (

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalJournal of the American Geriatrics Society
Volume59
Issue number1
DOIs
StatePublished - Jan 2011

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Osteoporotic Fractures
Odds Ratio
Confidence Intervals
Liquid Chromatography
25-hydroxyvitamin D
Mass Spectrometry
Cohort Studies
Prospective Studies
Health

Keywords

  • 25-hydroxyvitamin D
  • elderly men
  • frailty syndrome

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Ensrud, K. E., Blackwell, T. L., Cauley, J. A., Cummings, S. R., Barrett-Connor, E., Dam, T. T. L., ... Cawthon, P. M. (2011). Circulating 25-hydroxyvitamin D levels and frailty in older men: The osteoporotic fractures in men study. Journal of the American Geriatrics Society, 59(1), 101-106. https://doi.org/10.1111/j.1532-5415.2010.03201.x

Circulating 25-hydroxyvitamin D levels and frailty in older men : The osteoporotic fractures in men study. / Ensrud, Kristine E.; Blackwell, Terri L.; Cauley, Jane A.; Cummings, Steven R.; Barrett-Connor, Elizabeth; Dam, Thuy Tien L; Hoffman, Andrew R.; Shikany, James M.; Lane, Nancy E.; Stefanick, Marcia L.; Orwoll, Eric; Cawthon, Peggy M.

In: Journal of the American Geriatrics Society, Vol. 59, No. 1, 01.2011, p. 101-106.

Research output: Contribution to journalArticle

Ensrud, KE, Blackwell, TL, Cauley, JA, Cummings, SR, Barrett-Connor, E, Dam, TTL, Hoffman, AR, Shikany, JM, Lane, NE, Stefanick, ML, Orwoll, E & Cawthon, PM 2011, 'Circulating 25-hydroxyvitamin D levels and frailty in older men: The osteoporotic fractures in men study', Journal of the American Geriatrics Society, vol. 59, no. 1, pp. 101-106. https://doi.org/10.1111/j.1532-5415.2010.03201.x
Ensrud, Kristine E. ; Blackwell, Terri L. ; Cauley, Jane A. ; Cummings, Steven R. ; Barrett-Connor, Elizabeth ; Dam, Thuy Tien L ; Hoffman, Andrew R. ; Shikany, James M. ; Lane, Nancy E. ; Stefanick, Marcia L. ; Orwoll, Eric ; Cawthon, Peggy M. / Circulating 25-hydroxyvitamin D levels and frailty in older men : The osteoporotic fractures in men study. In: Journal of the American Geriatrics Society. 2011 ; Vol. 59, No. 1. pp. 101-106.
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abstract = "OBJECTIVES: To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men. DESIGN: Prospective cohort study. SETTING: Six U.S. community-based centers. PARTICIPANTS: One thousand six hundred six men aged 65 and older. MEASUREMENTS: 25(OH)D (liquid chromatography tandem mass spectroscopy) and frailty status (criteria similar to those used in the Cardiovascular Health Study) measured at baseline; frailty status assessment repeated an average of 4.6 years later. Frailty status was classified as robust, intermediate, or frail at baseline and robust, intermediate, frail, or dead at follow-up. RESULTS: After adjusting for multiple potential confounders, men with 25(OH)D levels less than 20.0 ng/mL had 1.5 times higher odds (multivariate odds ratio (MOR)=1.47, 95{\%} confidence interval (CI)=1.07-2.02) of greater frailty status at baseline than men with 25(OH)D levels of 30.0 ng/mL or greater (referent group), whereas frailty status was similar in men with 25(OH)D levels from 20.0 to 29.9 ng/mL and those with levels of 30.0 ng/mL or greater (MOR=1.02, 95{\%} CI=0.78-1.32). However, in 1,267 men not classified as frail at baseline, there was no association between lower baseline 25(OH)D level and odds of greater frailty status at the 4.6-year follow-up. Findings were the same when 25(OH)D was expressed in quartiles or as a continuous variable. CONCLUSION: Lower levels of 25(OH)D (",
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AU - Ensrud, Kristine E.

AU - Blackwell, Terri L.

AU - Cauley, Jane A.

AU - Cummings, Steven R.

AU - Barrett-Connor, Elizabeth

AU - Dam, Thuy Tien L

AU - Hoffman, Andrew R.

AU - Shikany, James M.

AU - Lane, Nancy E.

AU - Stefanick, Marcia L.

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N2 - OBJECTIVES: To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men. DESIGN: Prospective cohort study. SETTING: Six U.S. community-based centers. PARTICIPANTS: One thousand six hundred six men aged 65 and older. MEASUREMENTS: 25(OH)D (liquid chromatography tandem mass spectroscopy) and frailty status (criteria similar to those used in the Cardiovascular Health Study) measured at baseline; frailty status assessment repeated an average of 4.6 years later. Frailty status was classified as robust, intermediate, or frail at baseline and robust, intermediate, frail, or dead at follow-up. RESULTS: After adjusting for multiple potential confounders, men with 25(OH)D levels less than 20.0 ng/mL had 1.5 times higher odds (multivariate odds ratio (MOR)=1.47, 95% confidence interval (CI)=1.07-2.02) of greater frailty status at baseline than men with 25(OH)D levels of 30.0 ng/mL or greater (referent group), whereas frailty status was similar in men with 25(OH)D levels from 20.0 to 29.9 ng/mL and those with levels of 30.0 ng/mL or greater (MOR=1.02, 95% CI=0.78-1.32). However, in 1,267 men not classified as frail at baseline, there was no association between lower baseline 25(OH)D level and odds of greater frailty status at the 4.6-year follow-up. Findings were the same when 25(OH)D was expressed in quartiles or as a continuous variable. CONCLUSION: Lower levels of 25(OH)D (

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