Circuit and synaptic plasticity mechanisms of drug relapse

Yan Dong, Jane R. Taylor, Marina E. Wolf, Yavin Shaham

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


High rates of relapse to drug use during abstinence is a defining feature of human drug addiction. This clinical scenario has been studied at the preclinical level using different animal models in which relapse to drug seeking is assessed after cessation of operant drug self-administration in rodents and monkeys. In our Society for Neuroscience (SFN) session entitled “Circuit and Synaptic Plasticity Mechanisms of Drug Relapse,” we will discuss new developments of our understanding of circuits and synaptic plasticity mechanisms of drug relapse from studies combining established and novel animal models with state-of-the-art cellular, electrophysiology, anatomical, chemogenetic, and optogenetic methods. We will also discuss the translational implications of these new developments. In the mini-review that introduces our SFN session, we summarize results from our laboratories on behavioral, cellular, and circuit mechanisms of drug relapse within the context of our session.

Original languageEnglish (US)
Pages (from-to)10867-10876
Number of pages10
JournalJournal of Neuroscience
Issue number45
StatePublished - Nov 8 2017
Externally publishedYes


  • Alcohol
  • Circuit ablation
  • Cocaine
  • Daun02 inactivation
  • Diphtheria toxin receptors
  • Drug cues
  • Homeostatic plasticity
  • Incubation of drug craving
  • Reinstatement
  • Relapse
  • Silent synapse

ASJC Scopus subject areas

  • Neuroscience(all)


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