Circuit and synaptic plasticity mechanisms of drug relapse

Yan Dong, Jane R. Taylor, Marina Wolf, Yavin Shaham

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

High rates of relapse to drug use during abstinence is a defining feature of human drug addiction. This clinical scenario has been studied at the preclinical level using different animal models in which relapse to drug seeking is assessed after cessation of operant drug self-administration in rodents and monkeys. In our Society for Neuroscience (SFN) session entitled “Circuit and Synaptic Plasticity Mechanisms of Drug Relapse,” we will discuss new developments of our understanding of circuits and synaptic plasticity mechanisms of drug relapse from studies combining established and novel animal models with state-of-the-art cellular, electrophysiology, anatomical, chemogenetic, and optogenetic methods. We will also discuss the translational implications of these new developments. In the mini-review that introduces our SFN session, we summarize results from our laboratories on behavioral, cellular, and circuit mechanisms of drug relapse within the context of our session.

Original languageEnglish (US)
Pages (from-to)10867-10876
Number of pages10
JournalJournal of Neuroscience
Volume37
Issue number45
DOIs
StatePublished - Nov 8 2017
Externally publishedYes

Fingerprint

Neuronal Plasticity
Recurrence
Pharmaceutical Preparations
Animal Models
Optogenetics
Self Administration
Electrophysiology
Neurosciences
Substance-Related Disorders
Haplorhini
Rodentia

Keywords

  • Alcohol
  • Circuit ablation
  • Cocaine
  • CP-AMPARs
  • Daun02 inactivation
  • Diphtheria toxin receptors
  • Drug cues
  • Homeostatic plasticity
  • Incubation of drug craving
  • Reinstatement
  • Relapse
  • Silent synapse

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Circuit and synaptic plasticity mechanisms of drug relapse. / Dong, Yan; Taylor, Jane R.; Wolf, Marina; Shaham, Yavin.

In: Journal of Neuroscience, Vol. 37, No. 45, 08.11.2017, p. 10867-10876.

Research output: Contribution to journalArticle

Dong, Yan ; Taylor, Jane R. ; Wolf, Marina ; Shaham, Yavin. / Circuit and synaptic plasticity mechanisms of drug relapse. In: Journal of Neuroscience. 2017 ; Vol. 37, No. 45. pp. 10867-10876.
@article{9e43b27bc5844ef294e5373a8b38aafc,
title = "Circuit and synaptic plasticity mechanisms of drug relapse",
abstract = "High rates of relapse to drug use during abstinence is a defining feature of human drug addiction. This clinical scenario has been studied at the preclinical level using different animal models in which relapse to drug seeking is assessed after cessation of operant drug self-administration in rodents and monkeys. In our Society for Neuroscience (SFN) session entitled “Circuit and Synaptic Plasticity Mechanisms of Drug Relapse,” we will discuss new developments of our understanding of circuits and synaptic plasticity mechanisms of drug relapse from studies combining established and novel animal models with state-of-the-art cellular, electrophysiology, anatomical, chemogenetic, and optogenetic methods. We will also discuss the translational implications of these new developments. In the mini-review that introduces our SFN session, we summarize results from our laboratories on behavioral, cellular, and circuit mechanisms of drug relapse within the context of our session.",
keywords = "Alcohol, Circuit ablation, Cocaine, CP-AMPARs, Daun02 inactivation, Diphtheria toxin receptors, Drug cues, Homeostatic plasticity, Incubation of drug craving, Reinstatement, Relapse, Silent synapse",
author = "Yan Dong and Taylor, {Jane R.} and Marina Wolf and Yavin Shaham",
year = "2017",
month = "11",
day = "8",
doi = "10.1523/JNEUROSCI.1821-17.2017",
language = "English (US)",
volume = "37",
pages = "10867--10876",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "45",

}

TY - JOUR

T1 - Circuit and synaptic plasticity mechanisms of drug relapse

AU - Dong, Yan

AU - Taylor, Jane R.

AU - Wolf, Marina

AU - Shaham, Yavin

PY - 2017/11/8

Y1 - 2017/11/8

N2 - High rates of relapse to drug use during abstinence is a defining feature of human drug addiction. This clinical scenario has been studied at the preclinical level using different animal models in which relapse to drug seeking is assessed after cessation of operant drug self-administration in rodents and monkeys. In our Society for Neuroscience (SFN) session entitled “Circuit and Synaptic Plasticity Mechanisms of Drug Relapse,” we will discuss new developments of our understanding of circuits and synaptic plasticity mechanisms of drug relapse from studies combining established and novel animal models with state-of-the-art cellular, electrophysiology, anatomical, chemogenetic, and optogenetic methods. We will also discuss the translational implications of these new developments. In the mini-review that introduces our SFN session, we summarize results from our laboratories on behavioral, cellular, and circuit mechanisms of drug relapse within the context of our session.

AB - High rates of relapse to drug use during abstinence is a defining feature of human drug addiction. This clinical scenario has been studied at the preclinical level using different animal models in which relapse to drug seeking is assessed after cessation of operant drug self-administration in rodents and monkeys. In our Society for Neuroscience (SFN) session entitled “Circuit and Synaptic Plasticity Mechanisms of Drug Relapse,” we will discuss new developments of our understanding of circuits and synaptic plasticity mechanisms of drug relapse from studies combining established and novel animal models with state-of-the-art cellular, electrophysiology, anatomical, chemogenetic, and optogenetic methods. We will also discuss the translational implications of these new developments. In the mini-review that introduces our SFN session, we summarize results from our laboratories on behavioral, cellular, and circuit mechanisms of drug relapse within the context of our session.

KW - Alcohol

KW - Circuit ablation

KW - Cocaine

KW - CP-AMPARs

KW - Daun02 inactivation

KW - Diphtheria toxin receptors

KW - Drug cues

KW - Homeostatic plasticity

KW - Incubation of drug craving

KW - Reinstatement

KW - Relapse

KW - Silent synapse

UR - http://www.scopus.com/inward/record.url?scp=85033599080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033599080&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.1821-17.2017

DO - 10.1523/JNEUROSCI.1821-17.2017

M3 - Article

VL - 37

SP - 10867

EP - 10876

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 45

ER -