Circadian Rhythm of Vascular Function in Midlife Adults

Saurabh S. Thosar, Alec M. Berman, Maya X. Herzig, Andrew W. McHill, Nicole P. Bowles, Christine M. Swanson, Noal A. Clemons, Matthew Butler, Aaron A. Clemons, Jonathan Emens, Steven Shea

Research output: Contribution to journalArticle

Abstract

Objective- Adverse cardiovascular events occur more frequently in the morning than at other times of the day. Vascular endothelial function (VEF)-a robust cardiovascular risk marker-is impaired during this morning period. We recently discovered that this morning impairment in VEF is not caused by either overnight sleep or the inactivity that accompanies sleep. We determined whether the endogenous circadian system is responsible for this morning impairment in VEF. We also assessed whether the circadian system affects mechanistic biomarkers, that is, oxidative stress (malondialdehyde adducts), endothelin-1, blood pressure, and heart rate. Approach and Results- Twenty-one (11 women) middle-aged healthy participants completed a 5-day laboratory protocol in dim light where all behaviors, including sleep and activity, and all physiological measurements were evenly distributed across the 24-hour period. After baseline testing, participants underwent 10 recurring 5-hour 20-minute behavioral cycles of 2-hour 40-minute sleep opportunities and 2 hours and 40 minutes of standardized waking episodes. VEF, blood pressure, and heart rate were measured, and venous blood was sampled immediately after awakening during each wake episode. Independent of behaviors, VEF was significantly attenuated during the subjective night and across the morning ( P=0.04). Malondialdehyde adducts and endothelin-1 exhibited circadian rhythms with increases across the morning vulnerable period and peaks around noon ( P≤0.01). Both systolic ( P=0.005) and diastolic blood pressure ( P=0.04) were rhythmic with peaks in the late afternoon. Conclusions- The endogenous circadian system impairs VEF and increases malondialdehyde adducts and endothelin-1 in the morning vulnerable hours and may increase the risk of morning adverse cardiovascular events in susceptible individuals. Clinical Trial Registration- URL: http://www.clinicaltrials.gov . Unique identifier: NCT02202811.

Original languageEnglish (US)
Pages (from-to)1203-1211
Number of pages9
JournalArteriosclerosis, thrombosis, and vascular biology
Volume39
Issue number6
DOIs
StatePublished - Jun 1 2019
Externally publishedYes

Fingerprint

Circadian Rhythm
Blood Vessels
Sleep
Endothelin-1
Malondialdehyde
Blood Pressure
Heart Rate
Healthy Volunteers
Oxidative Stress
Biomarkers
Clinical Trials
Light

Keywords

  • adult
  • biomarkers
  • circadian rhythm
  • oxidative stress
  • sleep

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Thosar, S. S., Berman, A. M., Herzig, M. X., McHill, A. W., Bowles, N. P., Swanson, C. M., ... Shea, S. (2019). Circadian Rhythm of Vascular Function in Midlife Adults. Arteriosclerosis, thrombosis, and vascular biology, 39(6), 1203-1211. https://doi.org/10.1161/ATVBAHA.119.312682

Circadian Rhythm of Vascular Function in Midlife Adults. / Thosar, Saurabh S.; Berman, Alec M.; Herzig, Maya X.; McHill, Andrew W.; Bowles, Nicole P.; Swanson, Christine M.; Clemons, Noal A.; Butler, Matthew; Clemons, Aaron A.; Emens, Jonathan; Shea, Steven.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 39, No. 6, 01.06.2019, p. 1203-1211.

Research output: Contribution to journalArticle

Thosar, SS, Berman, AM, Herzig, MX, McHill, AW, Bowles, NP, Swanson, CM, Clemons, NA, Butler, M, Clemons, AA, Emens, J & Shea, S 2019, 'Circadian Rhythm of Vascular Function in Midlife Adults', Arteriosclerosis, thrombosis, and vascular biology, vol. 39, no. 6, pp. 1203-1211. https://doi.org/10.1161/ATVBAHA.119.312682
Thosar SS, Berman AM, Herzig MX, McHill AW, Bowles NP, Swanson CM et al. Circadian Rhythm of Vascular Function in Midlife Adults. Arteriosclerosis, thrombosis, and vascular biology. 2019 Jun 1;39(6):1203-1211. https://doi.org/10.1161/ATVBAHA.119.312682
Thosar, Saurabh S. ; Berman, Alec M. ; Herzig, Maya X. ; McHill, Andrew W. ; Bowles, Nicole P. ; Swanson, Christine M. ; Clemons, Noal A. ; Butler, Matthew ; Clemons, Aaron A. ; Emens, Jonathan ; Shea, Steven. / Circadian Rhythm of Vascular Function in Midlife Adults. In: Arteriosclerosis, thrombosis, and vascular biology. 2019 ; Vol. 39, No. 6. pp. 1203-1211.
@article{7430a9e4013344fa85672825b9876af3,
title = "Circadian Rhythm of Vascular Function in Midlife Adults",
abstract = "Objective- Adverse cardiovascular events occur more frequently in the morning than at other times of the day. Vascular endothelial function (VEF)-a robust cardiovascular risk marker-is impaired during this morning period. We recently discovered that this morning impairment in VEF is not caused by either overnight sleep or the inactivity that accompanies sleep. We determined whether the endogenous circadian system is responsible for this morning impairment in VEF. We also assessed whether the circadian system affects mechanistic biomarkers, that is, oxidative stress (malondialdehyde adducts), endothelin-1, blood pressure, and heart rate. Approach and Results- Twenty-one (11 women) middle-aged healthy participants completed a 5-day laboratory protocol in dim light where all behaviors, including sleep and activity, and all physiological measurements were evenly distributed across the 24-hour period. After baseline testing, participants underwent 10 recurring 5-hour 20-minute behavioral cycles of 2-hour 40-minute sleep opportunities and 2 hours and 40 minutes of standardized waking episodes. VEF, blood pressure, and heart rate were measured, and venous blood was sampled immediately after awakening during each wake episode. Independent of behaviors, VEF was significantly attenuated during the subjective night and across the morning ( P=0.04). Malondialdehyde adducts and endothelin-1 exhibited circadian rhythms with increases across the morning vulnerable period and peaks around noon ( P≤0.01). Both systolic ( P=0.005) and diastolic blood pressure ( P=0.04) were rhythmic with peaks in the late afternoon. Conclusions- The endogenous circadian system impairs VEF and increases malondialdehyde adducts and endothelin-1 in the morning vulnerable hours and may increase the risk of morning adverse cardiovascular events in susceptible individuals. Clinical Trial Registration- URL: http://www.clinicaltrials.gov . Unique identifier: NCT02202811.",
keywords = "adult, biomarkers, circadian rhythm, oxidative stress, sleep",
author = "Thosar, {Saurabh S.} and Berman, {Alec M.} and Herzig, {Maya X.} and McHill, {Andrew W.} and Bowles, {Nicole P.} and Swanson, {Christine M.} and Clemons, {Noal A.} and Matthew Butler and Clemons, {Aaron A.} and Jonathan Emens and Steven Shea",
year = "2019",
month = "6",
day = "1",
doi = "10.1161/ATVBAHA.119.312682",
language = "English (US)",
volume = "39",
pages = "1203--1211",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Circadian Rhythm of Vascular Function in Midlife Adults

AU - Thosar, Saurabh S.

AU - Berman, Alec M.

AU - Herzig, Maya X.

AU - McHill, Andrew W.

AU - Bowles, Nicole P.

AU - Swanson, Christine M.

AU - Clemons, Noal A.

AU - Butler, Matthew

AU - Clemons, Aaron A.

AU - Emens, Jonathan

AU - Shea, Steven

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Objective- Adverse cardiovascular events occur more frequently in the morning than at other times of the day. Vascular endothelial function (VEF)-a robust cardiovascular risk marker-is impaired during this morning period. We recently discovered that this morning impairment in VEF is not caused by either overnight sleep or the inactivity that accompanies sleep. We determined whether the endogenous circadian system is responsible for this morning impairment in VEF. We also assessed whether the circadian system affects mechanistic biomarkers, that is, oxidative stress (malondialdehyde adducts), endothelin-1, blood pressure, and heart rate. Approach and Results- Twenty-one (11 women) middle-aged healthy participants completed a 5-day laboratory protocol in dim light where all behaviors, including sleep and activity, and all physiological measurements were evenly distributed across the 24-hour period. After baseline testing, participants underwent 10 recurring 5-hour 20-minute behavioral cycles of 2-hour 40-minute sleep opportunities and 2 hours and 40 minutes of standardized waking episodes. VEF, blood pressure, and heart rate were measured, and venous blood was sampled immediately after awakening during each wake episode. Independent of behaviors, VEF was significantly attenuated during the subjective night and across the morning ( P=0.04). Malondialdehyde adducts and endothelin-1 exhibited circadian rhythms with increases across the morning vulnerable period and peaks around noon ( P≤0.01). Both systolic ( P=0.005) and diastolic blood pressure ( P=0.04) were rhythmic with peaks in the late afternoon. Conclusions- The endogenous circadian system impairs VEF and increases malondialdehyde adducts and endothelin-1 in the morning vulnerable hours and may increase the risk of morning adverse cardiovascular events in susceptible individuals. Clinical Trial Registration- URL: http://www.clinicaltrials.gov . Unique identifier: NCT02202811.

AB - Objective- Adverse cardiovascular events occur more frequently in the morning than at other times of the day. Vascular endothelial function (VEF)-a robust cardiovascular risk marker-is impaired during this morning period. We recently discovered that this morning impairment in VEF is not caused by either overnight sleep or the inactivity that accompanies sleep. We determined whether the endogenous circadian system is responsible for this morning impairment in VEF. We also assessed whether the circadian system affects mechanistic biomarkers, that is, oxidative stress (malondialdehyde adducts), endothelin-1, blood pressure, and heart rate. Approach and Results- Twenty-one (11 women) middle-aged healthy participants completed a 5-day laboratory protocol in dim light where all behaviors, including sleep and activity, and all physiological measurements were evenly distributed across the 24-hour period. After baseline testing, participants underwent 10 recurring 5-hour 20-minute behavioral cycles of 2-hour 40-minute sleep opportunities and 2 hours and 40 minutes of standardized waking episodes. VEF, blood pressure, and heart rate were measured, and venous blood was sampled immediately after awakening during each wake episode. Independent of behaviors, VEF was significantly attenuated during the subjective night and across the morning ( P=0.04). Malondialdehyde adducts and endothelin-1 exhibited circadian rhythms with increases across the morning vulnerable period and peaks around noon ( P≤0.01). Both systolic ( P=0.005) and diastolic blood pressure ( P=0.04) were rhythmic with peaks in the late afternoon. Conclusions- The endogenous circadian system impairs VEF and increases malondialdehyde adducts and endothelin-1 in the morning vulnerable hours and may increase the risk of morning adverse cardiovascular events in susceptible individuals. Clinical Trial Registration- URL: http://www.clinicaltrials.gov . Unique identifier: NCT02202811.

KW - adult

KW - biomarkers

KW - circadian rhythm

KW - oxidative stress

KW - sleep

UR - http://www.scopus.com/inward/record.url?scp=85066513376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066513376&partnerID=8YFLogxK

U2 - 10.1161/ATVBAHA.119.312682

DO - 10.1161/ATVBAHA.119.312682

M3 - Article

VL - 39

SP - 1203

EP - 1211

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 6

ER -