Circadian rhythm in negative affect: Implications for mood disorders

Jonathan S. Emens; Alec M. Berman; Saurabh S. Thosar; Matthew P. Butler; Sally A. Roberts; Noal A. Clemons; Maya X. Herzig; Andrew W. McHill; Miki Morimoto; Nicole P. Bowles; Steven A. Shea

doi:10.1016/j.psychres.2020.113337

Circadian rhythm in negative affect: Implications for mood disorders

Jonathan S. Emens, Alec M. Berman, Saurabh S. Thosar, Matthew P. Butler, Sally A. Roberts, Noal A. Clemons, Maya X. Herzig, Andrew W. McHill, Miki Morimoto, Nicole P. Bowles, Steven A. Shea

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

In humans, there is an endogenous, near 24-h (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp circadian peak in negative affect during the circadian night coincident with a circadian trough in positive affect. These findings may help explain the association of depression with insomnia, the increased risk of suicide with nocturnal wakefulness, and the correlation between circadian misalignment and symptom severity in Major Depressive Disorder.

Original language	English (US)
Article number	113337
Journal	Psychiatry Research
Volume	293
DOIs	https://doi.org/10.1016/j.psychres.2020.113337
State	Published - Nov 2020

Keywords

Circadian
Mood disorders
Sleep

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2020.113337

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title = "Circadian rhythm in negative affect: Implications for mood disorders",

abstract = "In humans, there is an endogenous, near 24-h (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp circadian peak in negative affect during the circadian night coincident with a circadian trough in positive affect. These findings may help explain the association of depression with insomnia, the increased risk of suicide with nocturnal wakefulness, and the correlation between circadian misalignment and symptom severity in Major Depressive Disorder.",

keywords = "Circadian, Mood disorders, Sleep",

author = "Emens, {Jonathan S.} and Berman, {Alec M.} and Thosar, {Saurabh S.} and Butler, {Matthew P.} and Roberts, {Sally A.} and Clemons, {Noal A.} and Herzig, {Maya X.} and McHill, {Andrew W.} and Miki Morimoto and Bowles, {Nicole P.} and Shea, {Steven A.}",

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year = "2020",

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doi = "10.1016/j.psychres.2020.113337",

language = "English (US)",

volume = "293",

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T2 - Implications for mood disorders

AU - Emens, Jonathan S.

AU - Berman, Alec M.

AU - Thosar, Saurabh S.

AU - Butler, Matthew P.

AU - Roberts, Sally A.

AU - Clemons, Noal A.

AU - Herzig, Maya X.

AU - McHill, Andrew W.

AU - Morimoto, Miki

AU - Bowles, Nicole P.

AU - Shea, Steven A.

PY - 2020/11

Y1 - 2020/11

N2 - In humans, there is an endogenous, near 24-h (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp circadian peak in negative affect during the circadian night coincident with a circadian trough in positive affect. These findings may help explain the association of depression with insomnia, the increased risk of suicide with nocturnal wakefulness, and the correlation between circadian misalignment and symptom severity in Major Depressive Disorder.

AB - In humans, there is an endogenous, near 24-h (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp circadian peak in negative affect during the circadian night coincident with a circadian trough in positive affect. These findings may help explain the association of depression with insomnia, the increased risk of suicide with nocturnal wakefulness, and the correlation between circadian misalignment and symptom severity in Major Depressive Disorder.

KW - Circadian

KW - Mood disorders

KW - Sleep

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Circadian rhythm in negative affect: Implications for mood disorders

Abstract

Keywords

ASJC Scopus subject areas

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