Circadian Regulation of Endocrine Functions

Matthew P. Butler, Ilia Karatsoreos, Lance J. Kriegsfeld, Rae Silver

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


The prominent circadian rhythms of the endocrine system are important for our broader understanding of physiology and behavior, in both health and disease. There is now much evidence that disruptions in the circadian domain, due to either external factors such as shift work or internal factors such as sleep disturbances, can lead to physiological and psychological pathologies. There is interest and urgency in understanding how time is coordinated in the body. A master circadian clock resides in the suprachiasmatic nucleus (SCN) of the hypothalamus. While this is the only tissue in which autonomous rhythms are self-sustaining, the molecular machinery is present in most peripheral cells. Rather than imposing time on the body then, the SCN entrains local clocks in a tissue-specific manner. These peripheral clocks then participate in controlling rhythmic transcription of genes associated with local tissue function. In this chapter, we examine the interplay between brain and peripheral clocks in the control of endocrine rhythms.

Original languageEnglish (US)
Title of host publicationMammalian Hormone-Behavior Systems
Number of pages25
ISBN (Print)9780128036082
StatePublished - Jan 1 2017


  • Adrenal
  • Aging
  • Circadian rhythm
  • Clock genes
  • Estrogen
  • Glucocorticoid
  • Gonad
  • Jet lag
  • Melatonin
  • Prolactin
  • Seasonality
  • Shift work

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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