Circadian misalignment in major depressive disorder

Jonathan Emens; Alfred Lewy; John Mark Kinzie; Diana Arntz; Jennifer Rough

doi:10.1016/j.psychres.2009.04.009

Circadian misalignment in major depressive disorder

Jonathan Emens, Alfred Lewy, John Mark Kinzie, Diana Arntz, Jennifer Rough

Research output: Contribution to journal › Article › peer-review

199 Scopus citations

Abstract

It has been hypothesized that the circadian pacemaker plays a role in major depressive disorder (MDD). We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms.

Original language	English (US)
Pages (from-to)	259-261
Number of pages	3
Journal	Psychiatry Research
Volume	168
Issue number	3
DOIs	https://doi.org/10.1016/j.psychres.2009.04.009
State	Published - Aug 15 2009

Keywords

Circadian rhythms
Depression
Dim light melatonin onset (DLMO)
Melatonin
Phase angle difference (PAD)
Sleep

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2009.04.009

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title = "Circadian misalignment in major depressive disorder",

abstract = "It has been hypothesized that the circadian pacemaker plays a role in major depressive disorder (MDD). We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms.",

keywords = "Circadian rhythms, Depression, Dim light melatonin onset (DLMO), Melatonin, Phase angle difference (PAD), Sleep",

author = "Jonathan Emens and Alfred Lewy and Kinzie, {John Mark} and Diana Arntz and Jennifer Rough",

note = "Funding Information: This study was supported by NARSAD (Young Investigator Award to J.S.E.) and Public Health Service Grants K23 RR017636 (to J.S.E.); R01 EY018312, R01 HD42125, and R01 AG21826 to AJL; and UL1 RR024140 (to the Oregon Clinical and Translational Research Institute).",

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AU - Emens, Jonathan

AU - Lewy, Alfred

AU - Kinzie, John Mark

AU - Arntz, Diana

AU - Rough, Jennifer

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Y1 - 2009/8/15

N2 - It has been hypothesized that the circadian pacemaker plays a role in major depressive disorder (MDD). We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms.

AB - It has been hypothesized that the circadian pacemaker plays a role in major depressive disorder (MDD). We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms.

KW - Circadian rhythms

KW - Depression

KW - Dim light melatonin onset (DLMO)

KW - Melatonin

KW - Phase angle difference (PAD)

KW - Sleep

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Circadian misalignment in major depressive disorder

Abstract

Keywords

ASJC Scopus subject areas

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