Circadian clock genes: Effects on dopamine, reward and addiction

Puja K. Parekh, Angela R. Ozburn, Colleen A. McClung

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations


Addiction is a widespread public health issue with social and economic ramifications. Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance of circadian molecular mechanisms can predispose some individuals to substance abuse disorders. In this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. We will also suggest future directions for research on circadian genes and drugs of abuse.

Original languageEnglish (US)
Pages (from-to)341-349
Number of pages9
Issue number4
StatePublished - Jun 1 2015


  • Addiction
  • Alcohol
  • Circadian
  • Dopamine

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience


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