Chronobiology of Acute Aortic Dissection in the Marfan Syndrome (from the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions and the International Registry of Acute Aortic Dissection)

Hasan K. Siddiqi, Steven N. Luminais, Dan Montgomery, Eduardo Bossone, Harry Dietz, Arturo Evangelista, Eric Isselbacher, Scott LeMaire, Roberto Manfredini, Dianna Milewicz, Christoph A. Nienaber, Mary Roman, Udo Sechtem, Gary (Michael) Silberbach, Kim A. Eagle, Reed E. Pyeritz

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Abstract

Marfan syndrome (MFS) is an autosomal dominant connective tissue disease associated with acute aortic dissection (AAD). We used 2 large registries that include patients with MFS to investigate possible trends in the chronobiology of AAD in MFS. We queried the International Registry of Acute Aortic Dissection (IRAD) and the Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) registry to extract data on all patients with MFS who had suffered an AAD. The group included 257 patients with MFS who suffered an AAD from 1980 to 2012. The chi-square tests were used for statistical testing. Mean subject age at time of AAD was 38 years, and 61% of subjects were men. AAD was more likely in the winter/spring season (November to April) than the other half of the year (57% vs 43%, p = 0.05). Dissections were significantly more likely to occur during the daytime hours, with 65% of dissections occurring from 6 A.M. to 6 P.M. (p = 0.001). Men were more likely to dissect during the daytime hours (6 A.M. to 6 P.M.) than women (74% vs 51%, p = 0.01). These insights offer a glimpse of the times of greatest vulnerability for patients with MFS who suffer from this catastrophic event. In conclusion, the chronobiology of AAD in MFS reflects that of AAD in the general population.

Original languageEnglish (US)
Pages (from-to)785-789
Number of pages5
JournalAmerican Journal of Cardiology
Volume119
Issue number5
DOIs
StatePublished - Mar 1 2017

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Thoracic Aortic Aneurysm
Marfan Syndrome
Registries
Dissection
Connective Tissue Diseases
Chi-Square Distribution

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Chronobiology of Acute Aortic Dissection in the Marfan Syndrome (from the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions and the International Registry of Acute Aortic Dissection). / Siddiqi, Hasan K.; Luminais, Steven N.; Montgomery, Dan; Bossone, Eduardo; Dietz, Harry; Evangelista, Arturo; Isselbacher, Eric; LeMaire, Scott; Manfredini, Roberto; Milewicz, Dianna; Nienaber, Christoph A.; Roman, Mary; Sechtem, Udo; Silberbach, Gary (Michael); Eagle, Kim A.; Pyeritz, Reed E.

In: American Journal of Cardiology, Vol. 119, No. 5, 01.03.2017, p. 785-789.

Research output: Contribution to journalArticle

Siddiqi, HK, Luminais, SN, Montgomery, D, Bossone, E, Dietz, H, Evangelista, A, Isselbacher, E, LeMaire, S, Manfredini, R, Milewicz, D, Nienaber, CA, Roman, M, Sechtem, U, Silberbach, GM, Eagle, KA & Pyeritz, RE 2017, 'Chronobiology of Acute Aortic Dissection in the Marfan Syndrome (from the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions and the International Registry of Acute Aortic Dissection)', American Journal of Cardiology, vol. 119, no. 5, pp. 785-789. https://doi.org/10.1016/j.amjcard.2016.11.021
Siddiqi, Hasan K. ; Luminais, Steven N. ; Montgomery, Dan ; Bossone, Eduardo ; Dietz, Harry ; Evangelista, Arturo ; Isselbacher, Eric ; LeMaire, Scott ; Manfredini, Roberto ; Milewicz, Dianna ; Nienaber, Christoph A. ; Roman, Mary ; Sechtem, Udo ; Silberbach, Gary (Michael) ; Eagle, Kim A. ; Pyeritz, Reed E. / Chronobiology of Acute Aortic Dissection in the Marfan Syndrome (from the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions and the International Registry of Acute Aortic Dissection). In: American Journal of Cardiology. 2017 ; Vol. 119, No. 5. pp. 785-789.
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abstract = "Marfan syndrome (MFS) is an autosomal dominant connective tissue disease associated with acute aortic dissection (AAD). We used 2 large registries that include patients with MFS to investigate possible trends in the chronobiology of AAD in MFS. We queried the International Registry of Acute Aortic Dissection (IRAD) and the Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) registry to extract data on all patients with MFS who had suffered an AAD. The group included 257 patients with MFS who suffered an AAD from 1980 to 2012. The chi-square tests were used for statistical testing. Mean subject age at time of AAD was 38 years, and 61{\%} of subjects were men. AAD was more likely in the winter/spring season (November to April) than the other half of the year (57{\%} vs 43{\%}, p = 0.05). Dissections were significantly more likely to occur during the daytime hours, with 65{\%} of dissections occurring from 6 A.M. to 6 P.M. (p = 0.001). Men were more likely to dissect during the daytime hours (6 A.M. to 6 P.M.) than women (74{\%} vs 51{\%}, p = 0.01). These insights offer a glimpse of the times of greatest vulnerability for patients with MFS who suffer from this catastrophic event. In conclusion, the chronobiology of AAD in MFS reflects that of AAD in the general population.",
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AU - Luminais, Steven N.

AU - Montgomery, Dan

AU - Bossone, Eduardo

AU - Dietz, Harry

AU - Evangelista, Arturo

AU - Isselbacher, Eric

AU - LeMaire, Scott

AU - Manfredini, Roberto

AU - Milewicz, Dianna

AU - Nienaber, Christoph A.

AU - Roman, Mary

AU - Sechtem, Udo

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AU - Eagle, Kim A.

AU - Pyeritz, Reed E.

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