Chronic staphylococcal osteomyelitis: treatment with regimens containing rifampin.

C. W. Norden, J. Fierer, Richard Bryant

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Experience with rifampin as a component of combination antibiotic therapy for chronic staphylococcal osteomyelitis was reviewed. These data included the preliminary results of a randomized, prospective trial of parenteral nafcillin alone vs. parenteral nafcillin plus oral rifampin; the results of use of rifampin in combination with other oral antibiotics for the treatment of chronic staphylococcal osteomyelitis; and experience with rifampin regimens at the Oregon Health Sciences University. A total of 28 patients are described in this report; 70% of those who received regimens including rifampin experienced an apparent cure of infection. Most patients whose infections were not cured had inadequate surgical therapy or were also infected with other bacteria. Staphylococcus aureus was eradicated from the sinus drainage of all but one patient. Although these results are encouraging, a larger number of patients and a longer follow-up period are required for an adequate evaluation of the place of rifampin in therapy for chronic staphylococcal osteomyelitis.

Original languageEnglish (US)
JournalReviews of Infectious Diseases
Volume5 Suppl 3
StatePublished - Jul 1983

Fingerprint

Osteomyelitis
Rifampin
Nafcillin
Therapeutics
Anti-Bacterial Agents
Infection
Staphylococcus aureus
Drainage
Bacteria
Health

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Chronic staphylococcal osteomyelitis : treatment with regimens containing rifampin. / Norden, C. W.; Fierer, J.; Bryant, Richard.

In: Reviews of Infectious Diseases, Vol. 5 Suppl 3, 07.1983.

Research output: Contribution to journalArticle

Norden, C. W. ; Fierer, J. ; Bryant, Richard. / Chronic staphylococcal osteomyelitis : treatment with regimens containing rifampin. In: Reviews of Infectious Diseases. 1983 ; Vol. 5 Suppl 3.
@article{2e4496be4cf54666be5dcd5755e0eb04,
title = "Chronic staphylococcal osteomyelitis: treatment with regimens containing rifampin.",
abstract = "Experience with rifampin as a component of combination antibiotic therapy for chronic staphylococcal osteomyelitis was reviewed. These data included the preliminary results of a randomized, prospective trial of parenteral nafcillin alone vs. parenteral nafcillin plus oral rifampin; the results of use of rifampin in combination with other oral antibiotics for the treatment of chronic staphylococcal osteomyelitis; and experience with rifampin regimens at the Oregon Health Sciences University. A total of 28 patients are described in this report; 70{\%} of those who received regimens including rifampin experienced an apparent cure of infection. Most patients whose infections were not cured had inadequate surgical therapy or were also infected with other bacteria. Staphylococcus aureus was eradicated from the sinus drainage of all but one patient. Although these results are encouraging, a larger number of patients and a longer follow-up period are required for an adequate evaluation of the place of rifampin in therapy for chronic staphylococcal osteomyelitis.",
author = "Norden, {C. W.} and J. Fierer and Richard Bryant",
year = "1983",
month = "7",
language = "English (US)",
volume = "5 Suppl 3",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",

}

TY - JOUR

T1 - Chronic staphylococcal osteomyelitis

T2 - treatment with regimens containing rifampin.

AU - Norden, C. W.

AU - Fierer, J.

AU - Bryant, Richard

PY - 1983/7

Y1 - 1983/7

N2 - Experience with rifampin as a component of combination antibiotic therapy for chronic staphylococcal osteomyelitis was reviewed. These data included the preliminary results of a randomized, prospective trial of parenteral nafcillin alone vs. parenteral nafcillin plus oral rifampin; the results of use of rifampin in combination with other oral antibiotics for the treatment of chronic staphylococcal osteomyelitis; and experience with rifampin regimens at the Oregon Health Sciences University. A total of 28 patients are described in this report; 70% of those who received regimens including rifampin experienced an apparent cure of infection. Most patients whose infections were not cured had inadequate surgical therapy or were also infected with other bacteria. Staphylococcus aureus was eradicated from the sinus drainage of all but one patient. Although these results are encouraging, a larger number of patients and a longer follow-up period are required for an adequate evaluation of the place of rifampin in therapy for chronic staphylococcal osteomyelitis.

AB - Experience with rifampin as a component of combination antibiotic therapy for chronic staphylococcal osteomyelitis was reviewed. These data included the preliminary results of a randomized, prospective trial of parenteral nafcillin alone vs. parenteral nafcillin plus oral rifampin; the results of use of rifampin in combination with other oral antibiotics for the treatment of chronic staphylococcal osteomyelitis; and experience with rifampin regimens at the Oregon Health Sciences University. A total of 28 patients are described in this report; 70% of those who received regimens including rifampin experienced an apparent cure of infection. Most patients whose infections were not cured had inadequate surgical therapy or were also infected with other bacteria. Staphylococcus aureus was eradicated from the sinus drainage of all but one patient. Although these results are encouraging, a larger number of patients and a longer follow-up period are required for an adequate evaluation of the place of rifampin in therapy for chronic staphylococcal osteomyelitis.

UR - http://www.scopus.com/inward/record.url?scp=0020789413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020789413&partnerID=8YFLogxK

M3 - Article

C2 - 6635439

AN - SCOPUS:0020789413

VL - 5 Suppl 3

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

ER -