Chronic psychostimulant exposure to adult, but not periadolescent rats reduces subsequent morphine antinociception

Michelle C. Cyr, Susan Ingram, Sue Aicher, Michael M. Morgan

Research output: Contribution to journalArticle

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Abstract

Preweanling methylphenidate (MPH) exposure produces a long lasting enhanced sensitivity to opioids. Two important questions are whether this enhancement is specific to the age of psychostimulant exposure and the type of psychostimulant. To answer these questions periadolescent (PD 35) and adult (PD 55) rats received daily injections of saline, MPH, or methamphetamine (METH) for 10 consecutive days. Two weeks later, acute morphine antinociception was assessed on the hot plate using a cumulative dose response procedure. Following acute antinociceptive testing, morphine tolerance was induced in half the animals by administering morphine twice a day over 2 days. Rats pretreated with MPH and METH during the periadolescent period of ontogeny showed no change in acute morphine antinociception, but rats exposed to a relatively high METH dose (3 mg/kg) displayed enhanced morphine tolerance compared to saline pretreated controls. MPH and METH pretreatment during adulthood led to a reduction in morphine antinociceptive potency and an apparent reduction in morphine tolerance. When combined with our previously published findings, these data indicate that the developmental stage during which MPH and METH exposure occurs differentially alters adult morphine responsiveness. That is, psychostimulant exposure to preweanling rats enhances morphine antinociception and facilitates the development of tolerance, whereas psychostimulant exposure to adult rats reduces subsequent morphine antinociception and tolerance. These alterations indicate that it could be important for physicians to know about prior psychostimulant use when prescribing opioids for pain relief.

Original languageEnglish (US)
Pages (from-to)538-543
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume101
Issue number4
DOIs
StatePublished - Jun 2012

Fingerprint

Morphine
Rats
Methylphenidate
Methamphetamine
Opioid Analgesics
Animals
Physicians
Pain
Injections
Testing

Keywords

  • Analgesia
  • Methamphetamine
  • Methylphenidate
  • Opioid
  • Pain modulation

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Pharmacology
  • Toxicology
  • Behavioral Neuroscience
  • Biological Psychiatry

Cite this

Chronic psychostimulant exposure to adult, but not periadolescent rats reduces subsequent morphine antinociception. / Cyr, Michelle C.; Ingram, Susan; Aicher, Sue; Morgan, Michael M.

In: Pharmacology Biochemistry and Behavior, Vol. 101, No. 4, 06.2012, p. 538-543.

Research output: Contribution to journalArticle

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