Chronic perilymphatic fistula

Experimental model in the guinea pig

Paul Flint, L. G. Duckert, R. A. Dobie, E. W. Rubel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Chronic perilymphatic fistulas were created in guinea pig cochleas using silicone rubber tubing placed into the scala tympani through the round window. Fistula patency was determined by fluorescein perfusion into cerebral spinal fluid. Fistulas were found to be patent in 6 of 6 animals at 7 days and 8 of 13 animals at 28 days. Analysis of ABRs revealed threshold increases of 10 to 15 dB across all frequencies at 1 hour and 7 days. However, thresholds returned to pre-fistula levels by 28 days. Animals with acute fistulas (simple laceration of the round window) had similar threshold increases at 1 hour; however, recovery to baseline levels occurred by day 7. Control animals with intact round windows did not have threshold shifts. Scanning electron microscopy revealed hair cell loss localized to the apical and basal turns of the cochlea. The morphologic changes observed occurred acutely (within 7 days) and were not progressive, despite the presence of a fistula. Hair cell loss or degeneration did not correlate with hearing loss.

Original languageEnglish (US)
Pages (from-to)380-388
Number of pages9
JournalOtolaryngology - Head and Neck Surgery
Volume99
Issue number4
StatePublished - 1988
Externally publishedYes

Fingerprint

Fistula
Guinea Pigs
Theoretical Models
Cochlea
Alopecia
Scala Tympani
Silicone Elastomers
Lacerations
Fluorescein
Hearing Loss
Electron Scanning Microscopy
Perfusion

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Chronic perilymphatic fistula : Experimental model in the guinea pig. / Flint, Paul; Duckert, L. G.; Dobie, R. A.; Rubel, E. W.

In: Otolaryngology - Head and Neck Surgery, Vol. 99, No. 4, 1988, p. 380-388.

Research output: Contribution to journalArticle

Flint, P, Duckert, LG, Dobie, RA & Rubel, EW 1988, 'Chronic perilymphatic fistula: Experimental model in the guinea pig', Otolaryngology - Head and Neck Surgery, vol. 99, no. 4, pp. 380-388.
Flint, Paul ; Duckert, L. G. ; Dobie, R. A. ; Rubel, E. W. / Chronic perilymphatic fistula : Experimental model in the guinea pig. In: Otolaryngology - Head and Neck Surgery. 1988 ; Vol. 99, No. 4. pp. 380-388.
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