TY - JOUR
T1 - Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells
AU - Schuh, Andre C.
AU - Sutherland, D. Robert
AU - Horsfall, Wendy
AU - Mills, Gordon B.
AU - Dube, Ian
AU - Baker, Michael A.
AU - Siminovitch, Kathy
AU - Bailey, Denis
AU - Keating, Armand
PY - 1990/9
Y1 - 1990/9
N2 - Until recently, T cells were believed not to be involved in chronic myeloid leukemia. We describe an example of CML in T lymphoblastic crisis with massive generalized lymphadenopathy in which the blasts were CD2(+), C05(+), and CD7(+), variably CD1(+) and CD3(+), and both responded to and could be induced to produce the T cell growth factor, interleukin-2. Additionally, the blasts were shown to contain the CML-related tyrosine kinase P210bcr-abl rather than the smaller kinase associated with Ph1(+) ALL. Finally, the participation of the T lymphoid lineage in the CML clone was proven by the presence of the same BCR rearrangement in blasts as in granulocytes, suggesting the existence of a bone marrow progenitor common to the T cell and myeloid lineages.
AB - Until recently, T cells were believed not to be involved in chronic myeloid leukemia. We describe an example of CML in T lymphoblastic crisis with massive generalized lymphadenopathy in which the blasts were CD2(+), C05(+), and CD7(+), variably CD1(+) and CD3(+), and both responded to and could be induced to produce the T cell growth factor, interleukin-2. Additionally, the blasts were shown to contain the CML-related tyrosine kinase P210bcr-abl rather than the smaller kinase associated with Ph1(+) ALL. Finally, the participation of the T lymphoid lineage in the CML clone was proven by the presence of the same BCR rearrangement in blasts as in granulocytes, suggesting the existence of a bone marrow progenitor common to the T cell and myeloid lineages.
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M3 - Article
C2 - 2168506
AN - SCOPUS:0025163478
VL - 4
SP - 631
EP - 636
JO - Leukemia
JF - Leukemia
SN - 0887-6924
IS - 9
ER -