Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells

Andre C. Schuh, D. Robert Sutherland, Wendy Horsfall, Gordon B. Mills, Ian Dube, Michael A. Baker, Kathy Siminovitch, Denis Bailey, Armand Keating

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Until recently, T cells were believed not to be involved in chronic myeloid leukemia. We describe an example of CML in T lymphoblastic crisis with massive generalized lymphadenopathy in which the blasts were CD2(+), C05(+), and CD7(+), variably CD1(+) and CD3(+), and both responded to and could be induced to produce the T cell growth factor, interleukin-2. Additionally, the blasts were shown to contain the CML-related tyrosine kinase P210bcr-abl rather than the smaller kinase associated with Ph1(+) ALL. Finally, the participation of the T lymphoid lineage in the CML clone was proven by the presence of the same BCR rearrangement in blasts as in granulocytes, suggesting the existence of a bone marrow progenitor common to the T cell and myeloid lineages.

Original languageEnglish (US)
Pages (from-to)631-636
Number of pages6
JournalLeukemia
Volume4
Issue number9
StatePublished - Sep 1990
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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