Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells

Andre C. Schuh, D. Robert Sutherland, Wendy Horsfall, Gordon Mills, Ian Dube, Michael A. Baker, Kathy Siminovitch, Denis Bailey, Armand Keating

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Until recently, T cells were believed not to be involved in chronic myeloid leukemia. We describe an example of CML in T lymphoblastic crisis with massive generalized lymphadenopathy in which the blasts were CD2(+), C05(+), and CD7(+), variably CD1(+) and CD3(+), and both responded to and could be induced to produce the T cell growth factor, interleukin-2. Additionally, the blasts were shown to contain the CML-related tyrosine kinase P210bcr-abl rather than the smaller kinase associated with Ph1(+) ALL. Finally, the participation of the T lymphoid lineage in the CML clone was proven by the presence of the same BCR rearrangement in blasts as in granulocytes, suggesting the existence of a bone marrow progenitor common to the T cell and myeloid lineages.

Original languageEnglish (US)
Pages (from-to)631-636
Number of pages6
JournalLeukemia
Volume4
Issue number9
StatePublished - Sep 1 1990
Externally publishedYes

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Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interleukin-2
T-Lymphocytes
Cell Lineage
Granulocytes
Protein-Tyrosine Kinases
Phosphotransferases
Clone Cells
Bone Marrow
Lymphadenopathy

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Schuh, A. C., Sutherland, D. R., Horsfall, W., Mills, G., Dube, I., Baker, M. A., ... Keating, A. (1990). Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells. Leukemia, 4(9), 631-636.

Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells. / Schuh, Andre C.; Sutherland, D. Robert; Horsfall, Wendy; Mills, Gordon; Dube, Ian; Baker, Michael A.; Siminovitch, Kathy; Bailey, Denis; Keating, Armand.

In: Leukemia, Vol. 4, No. 9, 01.09.1990, p. 631-636.

Research output: Contribution to journalArticle

Schuh, AC, Sutherland, DR, Horsfall, W, Mills, G, Dube, I, Baker, MA, Siminovitch, K, Bailey, D & Keating, A 1990, 'Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells', Leukemia, vol. 4, no. 9, pp. 631-636.
Schuh AC, Sutherland DR, Horsfall W, Mills G, Dube I, Baker MA et al. Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells. Leukemia. 1990 Sep 1;4(9):631-636.
Schuh, Andre C. ; Sutherland, D. Robert ; Horsfall, Wendy ; Mills, Gordon ; Dube, Ian ; Baker, Michael A. ; Siminovitch, Kathy ; Bailey, Denis ; Keating, Armand. / Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells. In: Leukemia. 1990 ; Vol. 4, No. 9. pp. 631-636.
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