Abstract
Until recently, T cells were believed not to be involved in chronic myeloid leukemia. We describe an example of CML in T lymphoblastic crisis with massive generalized lymphadenopathy in which the blasts were CD2(+), C05(+), and CD7(+), variably CD1(+) and CD3(+), and both responded to and could be induced to produce the T cell growth factor, interleukin-2. Additionally, the blasts were shown to contain the CML-related tyrosine kinase P210bcr-abl rather than the smaller kinase associated with Ph1(+) ALL. Finally, the participation of the T lymphoid lineage in the CML clone was proven by the presence of the same BCR rearrangement in blasts as in granulocytes, suggesting the existence of a bone marrow progenitor common to the T cell and myeloid lineages.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 631-636 |
| Number of pages | 6 |
| Journal | Leukemia |
| Volume | 4 |
| Issue number | 9 |
| State | Published - Sep 1 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Hematology
- Cancer Research
Cite this
Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells. / Schuh, Andre C.; Sutherland, D. Robert; Horsfall, Wendy; Mills, Gordon; Dube, Ian; Baker, Michael A.; Siminovitch, Kathy; Bailey, Denis; Keating, Armand.
In: Leukemia, Vol. 4, No. 9, 01.09.1990, p. 631-636.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells
AU - Schuh, Andre C.
AU - Sutherland, D. Robert
AU - Horsfall, Wendy
AU - Mills, Gordon
AU - Dube, Ian
AU - Baker, Michael A.
AU - Siminovitch, Kathy
AU - Bailey, Denis
AU - Keating, Armand
PY - 1990/9/1
Y1 - 1990/9/1
N2 - Until recently, T cells were believed not to be involved in chronic myeloid leukemia. We describe an example of CML in T lymphoblastic crisis with massive generalized lymphadenopathy in which the blasts were CD2(+), C05(+), and CD7(+), variably CD1(+) and CD3(+), and both responded to and could be induced to produce the T cell growth factor, interleukin-2. Additionally, the blasts were shown to contain the CML-related tyrosine kinase P210bcr-abl rather than the smaller kinase associated with Ph1(+) ALL. Finally, the participation of the T lymphoid lineage in the CML clone was proven by the presence of the same BCR rearrangement in blasts as in granulocytes, suggesting the existence of a bone marrow progenitor common to the T cell and myeloid lineages.
AB - Until recently, T cells were believed not to be involved in chronic myeloid leukemia. We describe an example of CML in T lymphoblastic crisis with massive generalized lymphadenopathy in which the blasts were CD2(+), C05(+), and CD7(+), variably CD1(+) and CD3(+), and both responded to and could be induced to produce the T cell growth factor, interleukin-2. Additionally, the blasts were shown to contain the CML-related tyrosine kinase P210bcr-abl rather than the smaller kinase associated with Ph1(+) ALL. Finally, the participation of the T lymphoid lineage in the CML clone was proven by the presence of the same BCR rearrangement in blasts as in granulocytes, suggesting the existence of a bone marrow progenitor common to the T cell and myeloid lineages.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025163478&partnerID=8YFLogxK
M3 - Article
C2 - 2168506
AN - SCOPUS:0025163478
VL - 4
SP - 631
EP - 636
JO - Leukemia
JF - Leukemia
SN - 0887-6924
IS - 9
ER -