Chronic myelogenous leukemia

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Chronic myelogenous leukemia is a clonal hematopoietic stem disorder characterized by excess numbers of myeloid cells that over time, lose the capacity for terminal differentiation. A series of discoveries led to the identification of the BCR-ABL tyrosine kinase as the cause of the disease and this provided the impetus for the development of specific agents that target this abnormality. This has also led to improved methods for diagnosis and molecular monitoring of patients with the disease.

Original languageEnglish (US)
Title of host publicationPrinciples of Molecular Medicine
PublisherHumana Press
Pages789-793
Number of pages5
ISBN (Print)9781588292025
DOIs
StatePublished - Dec 1 2006

Keywords

  • Allogeneic stem cell transplant
  • BCR-ABL
  • Philadelphia chromosome
  • RT-PCR
  • chronic myelogenous leukemia
  • imatinib
  • molecular monitoring
  • tyrosine kinase
  • tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Druker, B. J. (2006). Chronic myelogenous leukemia. In Principles of Molecular Medicine (pp. 789-793). Humana Press. https://doi.org/10.1007/978-1-59259-963-9_81