Chronic myelogenous leukemia

Brian J. Druker

doi:10.1007/978-1-59259-963-9_81

Chronic myelogenous leukemia

Brian J. Druker

Knight Cancer Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Chronic myelogenous leukemia is a clonal hematopoietic stem disorder characterized by excess numbers of myeloid cells that over time, lose the capacity for terminal differentiation. A series of discoveries led to the identification of the BCR-ABL tyrosine kinase as the cause of the disease and this provided the impetus for the development of specific agents that target this abnormality. This has also led to improved methods for diagnosis and molecular monitoring of patients with the disease.

Original language	English (US)
Title of host publication	Principles of Molecular Medicine
Publisher	Humana Press
Pages	789-793
Number of pages	5
ISBN (Print)	9781588292025
DOIs	https://doi.org/10.1007/978-1-59259-963-9_81
State	Published - 2006

Keywords

Allogeneic stem cell transplant
BCR-ABL
Philadelphia chromosome
RT-PCR
chronic myelogenous leukemia
imatinib
molecular monitoring
tyrosine kinase
tyrosine kinase inhibitors

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-59259-963-9_81

Cite this

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abstract = "Chronic myelogenous leukemia is a clonal hematopoietic stem disorder characterized by excess numbers of myeloid cells that over time, lose the capacity for terminal differentiation. A series of discoveries led to the identification of the BCR-ABL tyrosine kinase as the cause of the disease and this provided the impetus for the development of specific agents that target this abnormality. This has also led to improved methods for diagnosis and molecular monitoring of patients with the disease.",

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AB - Chronic myelogenous leukemia is a clonal hematopoietic stem disorder characterized by excess numbers of myeloid cells that over time, lose the capacity for terminal differentiation. A series of discoveries led to the identification of the BCR-ABL tyrosine kinase as the cause of the disease and this provided the impetus for the development of specific agents that target this abnormality. This has also led to improved methods for diagnosis and molecular monitoring of patients with the disease.

KW - Allogeneic stem cell transplant

KW - BCR-ABL

KW - Philadelphia chromosome

KW - RT-PCR

KW - chronic myelogenous leukemia

KW - imatinib

KW - molecular monitoring

KW - tyrosine kinase

KW - tyrosine kinase inhibitors

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PB - Humana Press

ER -

Chronic myelogenous leukemia

Abstract

Keywords

ASJC Scopus subject areas

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