Chronic graft-versus-host disease

Richard T. Maziarz, Farnoush Abar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chronic graft-versus-host disease (cGvHD) is the single major factor influencing long-term outcome and quality of life after allogeneic transplantation. However, the presence of cGvHD has been linked to decrease in relapse rate of patients with CML, ALL, and AML. In a recent CIBMTR/NMDP analysis of ∼3500 transplant patients with cGvHD, risk of relapse was reduced by 50%. Traditionally, cGvHD has been defined as occurring after day + 100, this entity has been documented as early as 50 days to years after the transplant procedure. Chronic GvHD can emerge during or immediately following taper of immune suppressive agents or may occur as part of a continuous spectrum merging acute GvHD into cGvHD (progressive GvHD).

Original languageEnglish (US)
Title of host publicationBlood and Marrow Transplant Handbook
Subtitle of host publicationComprehensive Guide for Patient Care
PublisherSpringer New York
Pages189-212
Number of pages24
ISBN (Print)9781441975058
DOIs
StatePublished - Dec 1 2011

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Maziarz, R. T., & Abar, F. (2011). Chronic graft-versus-host disease. In Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care (pp. 189-212). Springer New York. https://doi.org/10.1007/978-1-4419-7506-5_16