Chronic ethanol drinking increases during the luteal menstrual cycle phase in rhesus monkeys

implication of progesterone and related neurosteroids

Brandy Dozier, Cara A. Stull, Erich J. Baker, Matthew Ford, Jeremiah P. Jensen, Deborah (Deb) Finn, Kathleen (Kathy) Grant

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Rationale: Sporadic reports of alcohol consumption being linked to menstrual cycle phase highlight the need to consider hormonally characterized menstrual cycle phase in understanding the sex-specific effects of risk for alcohol drinking in women. Objectives: We investigated the association between menstrual cycle phase, characterized by circulating progesterone and menses, with accurate daily alcohol intakes in rhesus monkeys, and the contribution of progesterone derived neuroactive steroids to cycle-related alcohol drinking. Methods: Menses (daily) and progesterone (2–3×/week) were obtained in female monkeys (n = 8, 5 ethanol, 3 control) for 12–18 months. Ethanol monkeys were then induced to drink ethanol (4% w/v; 3 months) and given 22 h/day access to ethanol and water for approximately 1 year. In selected cycles, a panel of neuroactive steroids were assayed during follicular and luteal phases from pre-ethanol and ethanol exposure. Results: There were minimal to no effects of ethanol on menstrual cycle length, progesterone levels, and follicular or luteal phase length. The monkeys drank more ethanol during the luteal phase, compared to the follicular phase, and ethanol intake was highest in the late luteal phase when progesterone declines rapidly. Two neuroactive steroids were higher during the luteal phase versus the follicular phase, and several neuroactive steroids were higher in the pre- vs. post-ethanol drinking menstrual cycles. Conclusions: This is the first study to show that normal menstrual cycle fluctuations in progesterone, particularly during the late luteal phase, can modulate ethanol intake. Two of 11 neuroactive steroids were selectively associated with the effect of cycle progesterone on ethanol drinking, suggesting possible links to CNS mechanisms of ethanol intake control.

Original languageEnglish (US)
JournalPsychopharmacology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Luteal Phase
Macaca mulatta
Drinking
Progesterone
Neurotransmitter Agents
Ethanol
Menstrual Cycle
Follicular Phase
Steroids
Alcohol Drinking
Haplorhini
Menstruation

Keywords

  • Alcohol
  • Female
  • Luteal phase
  • Menstrual cycle
  • Monkey
  • Neurosteroid
  • Progesterone
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{3fe2da962afd452186157a3cc0501ee6,
title = "Chronic ethanol drinking increases during the luteal menstrual cycle phase in rhesus monkeys: implication of progesterone and related neurosteroids",
abstract = "Rationale: Sporadic reports of alcohol consumption being linked to menstrual cycle phase highlight the need to consider hormonally characterized menstrual cycle phase in understanding the sex-specific effects of risk for alcohol drinking in women. Objectives: We investigated the association between menstrual cycle phase, characterized by circulating progesterone and menses, with accurate daily alcohol intakes in rhesus monkeys, and the contribution of progesterone derived neuroactive steroids to cycle-related alcohol drinking. Methods: Menses (daily) and progesterone (2–3×/week) were obtained in female monkeys (n = 8, 5 ethanol, 3 control) for 12–18 months. Ethanol monkeys were then induced to drink ethanol (4{\%} w/v; 3 months) and given 22 h/day access to ethanol and water for approximately 1 year. In selected cycles, a panel of neuroactive steroids were assayed during follicular and luteal phases from pre-ethanol and ethanol exposure. Results: There were minimal to no effects of ethanol on menstrual cycle length, progesterone levels, and follicular or luteal phase length. The monkeys drank more ethanol during the luteal phase, compared to the follicular phase, and ethanol intake was highest in the late luteal phase when progesterone declines rapidly. Two neuroactive steroids were higher during the luteal phase versus the follicular phase, and several neuroactive steroids were higher in the pre- vs. post-ethanol drinking menstrual cycles. Conclusions: This is the first study to show that normal menstrual cycle fluctuations in progesterone, particularly during the late luteal phase, can modulate ethanol intake. Two of 11 neuroactive steroids were selectively associated with the effect of cycle progesterone on ethanol drinking, suggesting possible links to CNS mechanisms of ethanol intake control.",
keywords = "Alcohol, Female, Luteal phase, Menstrual cycle, Monkey, Neurosteroid, Progesterone, Self-administration",
author = "Brandy Dozier and Stull, {Cara A.} and Baker, {Erich J.} and Matthew Ford and Jensen, {Jeremiah P.} and Finn, {Deborah (Deb)} and Grant, {Kathleen (Kathy)}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00213-019-5168-9",
language = "English (US)",
journal = "Psychopharmacology",
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publisher = "Springer Verlag",

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TY - JOUR

T1 - Chronic ethanol drinking increases during the luteal menstrual cycle phase in rhesus monkeys

T2 - implication of progesterone and related neurosteroids

AU - Dozier, Brandy

AU - Stull, Cara A.

AU - Baker, Erich J.

AU - Ford, Matthew

AU - Jensen, Jeremiah P.

AU - Finn, Deborah (Deb)

AU - Grant, Kathleen (Kathy)

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Rationale: Sporadic reports of alcohol consumption being linked to menstrual cycle phase highlight the need to consider hormonally characterized menstrual cycle phase in understanding the sex-specific effects of risk for alcohol drinking in women. Objectives: We investigated the association between menstrual cycle phase, characterized by circulating progesterone and menses, with accurate daily alcohol intakes in rhesus monkeys, and the contribution of progesterone derived neuroactive steroids to cycle-related alcohol drinking. Methods: Menses (daily) and progesterone (2–3×/week) were obtained in female monkeys (n = 8, 5 ethanol, 3 control) for 12–18 months. Ethanol monkeys were then induced to drink ethanol (4% w/v; 3 months) and given 22 h/day access to ethanol and water for approximately 1 year. In selected cycles, a panel of neuroactive steroids were assayed during follicular and luteal phases from pre-ethanol and ethanol exposure. Results: There were minimal to no effects of ethanol on menstrual cycle length, progesterone levels, and follicular or luteal phase length. The monkeys drank more ethanol during the luteal phase, compared to the follicular phase, and ethanol intake was highest in the late luteal phase when progesterone declines rapidly. Two neuroactive steroids were higher during the luteal phase versus the follicular phase, and several neuroactive steroids were higher in the pre- vs. post-ethanol drinking menstrual cycles. Conclusions: This is the first study to show that normal menstrual cycle fluctuations in progesterone, particularly during the late luteal phase, can modulate ethanol intake. Two of 11 neuroactive steroids were selectively associated with the effect of cycle progesterone on ethanol drinking, suggesting possible links to CNS mechanisms of ethanol intake control.

AB - Rationale: Sporadic reports of alcohol consumption being linked to menstrual cycle phase highlight the need to consider hormonally characterized menstrual cycle phase in understanding the sex-specific effects of risk for alcohol drinking in women. Objectives: We investigated the association between menstrual cycle phase, characterized by circulating progesterone and menses, with accurate daily alcohol intakes in rhesus monkeys, and the contribution of progesterone derived neuroactive steroids to cycle-related alcohol drinking. Methods: Menses (daily) and progesterone (2–3×/week) were obtained in female monkeys (n = 8, 5 ethanol, 3 control) for 12–18 months. Ethanol monkeys were then induced to drink ethanol (4% w/v; 3 months) and given 22 h/day access to ethanol and water for approximately 1 year. In selected cycles, a panel of neuroactive steroids were assayed during follicular and luteal phases from pre-ethanol and ethanol exposure. Results: There were minimal to no effects of ethanol on menstrual cycle length, progesterone levels, and follicular or luteal phase length. The monkeys drank more ethanol during the luteal phase, compared to the follicular phase, and ethanol intake was highest in the late luteal phase when progesterone declines rapidly. Two neuroactive steroids were higher during the luteal phase versus the follicular phase, and several neuroactive steroids were higher in the pre- vs. post-ethanol drinking menstrual cycles. Conclusions: This is the first study to show that normal menstrual cycle fluctuations in progesterone, particularly during the late luteal phase, can modulate ethanol intake. Two of 11 neuroactive steroids were selectively associated with the effect of cycle progesterone on ethanol drinking, suggesting possible links to CNS mechanisms of ethanol intake control.

KW - Alcohol

KW - Female

KW - Luteal phase

KW - Menstrual cycle

KW - Monkey

KW - Neurosteroid

KW - Progesterone

KW - Self-administration

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U2 - 10.1007/s00213-019-5168-9

DO - 10.1007/s00213-019-5168-9

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JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

ER -