Chronic estradiol administration did not cause loss of hypothalamic LHRH or TIDA neurons in young or middle-aged C57BL/6J mice

Steven Kohama, S. A. Brown, C. E. Finch, T. H. McNeill

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Age-related decline in estrous cycle frequency and impaired pre-ovulatory gonadotropin surges at mid-life are modelled in young C57BL/6J mice by chronic (3 months) oral administration of estradiol (E2). However, the cellular events that induce damage to the neuroendocrine center that regulate gonadotropins with age or following E2 treatment are unclear. To address this issue, possible neuron loss was examined in relation to the loss of estrous cyclicity in E2-treated mice, in particular neurons of the hypothalamic luteinizing hormone releasing hormone (LHRH) and/or tuberoinfundibular dopaminergic (TIDA) systems. By immunocytochemical methods, there was no change in the number of LHRH or TIDA neurons in mice that have become acyclic due to age or E2 treatment. We conclude that the onset of acyclicity at middle-age or following chronic E2 treatment is not associated with loss of LHRH or TIDA neurons and that other neuroendocrine changes must be considered for the cause of acyclicity, particularly those involved in the synaptic regulation of LHRH secretion.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
JournalBrain Research
Volume574
Issue number1-2
DOIs
StatePublished - Mar 6 1992
Externally publishedYes

Fingerprint

Hypothalamic Hormones
Dopaminergic Neurons
Inbred C57BL Mouse
Gonadotropin-Releasing Hormone
Estradiol
Gonadotropins
Neurons
Estrous Cycle
Periodicity
Oral Administration
Therapeutics

Keywords

  • Estradiol
  • LHRH neuron
  • Mouse
  • Reproductive senescence
  • Tuberoinfundibular dopaminergic neuron

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Chronic estradiol administration did not cause loss of hypothalamic LHRH or TIDA neurons in young or middle-aged C57BL/6J mice. / Kohama, Steven; Brown, S. A.; Finch, C. E.; McNeill, T. H.

In: Brain Research, Vol. 574, No. 1-2, 06.03.1992, p. 341-344.

Research output: Contribution to journalArticle

Kohama, Steven ; Brown, S. A. ; Finch, C. E. ; McNeill, T. H. / Chronic estradiol administration did not cause loss of hypothalamic LHRH or TIDA neurons in young or middle-aged C57BL/6J mice. In: Brain Research. 1992 ; Vol. 574, No. 1-2. pp. 341-344.
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