Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

Joseph Quinn, Joseph R. Bussiere, Rebecca S. Hammond, Thomas J. Montine, Edward Henson, Richard E. Jones, Robert W. Stackman

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology. Here, the effects of the antioxidant, α-lipoic acid (ALA) were tested on the Tg2576 mouse, a transgenic model of cerebral amyloidosis associated with AD. Ten-month old Tg2576 and wild type mice were fed an ALA-containing diet (0.1%) or control diet for 6 months and then assessed for the influence of diet on memory and neuropathology. ALA-treated Tg2576 mice exhibited significantly improved learning, and memory retention in the Morris water maze task compared to untreated Tg2576 mice. Twenty-four hours after contextual fear conditioning, untreated Tg2576 mice exhibited significantly impaired context-dependent freezing. ALA-treated Tg2576 mice exhibited significantly more context freezing than the untreated Tg2576 mice. Assessment of brain soluble and insoluble β-amyloid levels revealed no differences between ALA-treated and untreated Tg2576 mice. Brain levels of nitrotyrosine, a marker of nitrative stress, were elevated in Tg2576 mice, while F2 isoprostanes and neuroprostanes, oxidative stress markers, were not elevated in the Tg2576 mice relative to wild type. These data indicate that chronic dietary ALA can reduce hippocampal-dependent memory deficits of Tg2576 mice without affecting β-amyloid levels or plaque deposition.

Original languageEnglish (US)
Pages (from-to)213-225
Number of pages13
JournalNeurobiology of Aging
Volume28
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

Fingerprint

Thioctic Acid
Antioxidants
Diet
Amyloid
Freezing
Neuroprostanes
Alzheimer Disease
Oxidative Stress
F2-Isoprostanes
Memory Disorders
Brain
Transgenic Mice
Fear
Learning

Keywords

  • Alzheimer's disease
  • Amyloid
  • Antioxidant
  • Context memory
  • Hippocampus
  • Nitrotyrosine
  • Spatial memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Quinn, J., Bussiere, J. R., Hammond, R. S., Montine, T. J., Henson, E., Jones, R. E., & Stackman, R. W. (2007). Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. Neurobiology of Aging, 28(2), 213-225. https://doi.org/10.1016/j.neurobiolaging.2005.12.014

Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. / Quinn, Joseph; Bussiere, Joseph R.; Hammond, Rebecca S.; Montine, Thomas J.; Henson, Edward; Jones, Richard E.; Stackman, Robert W.

In: Neurobiology of Aging, Vol. 28, No. 2, 02.2007, p. 213-225.

Research output: Contribution to journalArticle

Quinn, J, Bussiere, JR, Hammond, RS, Montine, TJ, Henson, E, Jones, RE & Stackman, RW 2007, 'Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice', Neurobiology of Aging, vol. 28, no. 2, pp. 213-225. https://doi.org/10.1016/j.neurobiolaging.2005.12.014
Quinn, Joseph ; Bussiere, Joseph R. ; Hammond, Rebecca S. ; Montine, Thomas J. ; Henson, Edward ; Jones, Richard E. ; Stackman, Robert W. / Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. In: Neurobiology of Aging. 2007 ; Vol. 28, No. 2. pp. 213-225.
@article{5ab116414d064fcb9fcf4ac8e68260bf,
title = "Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice",
abstract = "Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology. Here, the effects of the antioxidant, α-lipoic acid (ALA) were tested on the Tg2576 mouse, a transgenic model of cerebral amyloidosis associated with AD. Ten-month old Tg2576 and wild type mice were fed an ALA-containing diet (0.1{\%}) or control diet for 6 months and then assessed for the influence of diet on memory and neuropathology. ALA-treated Tg2576 mice exhibited significantly improved learning, and memory retention in the Morris water maze task compared to untreated Tg2576 mice. Twenty-four hours after contextual fear conditioning, untreated Tg2576 mice exhibited significantly impaired context-dependent freezing. ALA-treated Tg2576 mice exhibited significantly more context freezing than the untreated Tg2576 mice. Assessment of brain soluble and insoluble β-amyloid levels revealed no differences between ALA-treated and untreated Tg2576 mice. Brain levels of nitrotyrosine, a marker of nitrative stress, were elevated in Tg2576 mice, while F2 isoprostanes and neuroprostanes, oxidative stress markers, were not elevated in the Tg2576 mice relative to wild type. These data indicate that chronic dietary ALA can reduce hippocampal-dependent memory deficits of Tg2576 mice without affecting β-amyloid levels or plaque deposition.",
keywords = "Alzheimer's disease, Amyloid, Antioxidant, Context memory, Hippocampus, Nitrotyrosine, Spatial memory",
author = "Joseph Quinn and Bussiere, {Joseph R.} and Hammond, {Rebecca S.} and Montine, {Thomas J.} and Edward Henson and Jones, {Richard E.} and Stackman, {Robert W.}",
year = "2007",
month = "2",
doi = "10.1016/j.neurobiolaging.2005.12.014",
language = "English (US)",
volume = "28",
pages = "213--225",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

AU - Quinn, Joseph

AU - Bussiere, Joseph R.

AU - Hammond, Rebecca S.

AU - Montine, Thomas J.

AU - Henson, Edward

AU - Jones, Richard E.

AU - Stackman, Robert W.

PY - 2007/2

Y1 - 2007/2

N2 - Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology. Here, the effects of the antioxidant, α-lipoic acid (ALA) were tested on the Tg2576 mouse, a transgenic model of cerebral amyloidosis associated with AD. Ten-month old Tg2576 and wild type mice were fed an ALA-containing diet (0.1%) or control diet for 6 months and then assessed for the influence of diet on memory and neuropathology. ALA-treated Tg2576 mice exhibited significantly improved learning, and memory retention in the Morris water maze task compared to untreated Tg2576 mice. Twenty-four hours after contextual fear conditioning, untreated Tg2576 mice exhibited significantly impaired context-dependent freezing. ALA-treated Tg2576 mice exhibited significantly more context freezing than the untreated Tg2576 mice. Assessment of brain soluble and insoluble β-amyloid levels revealed no differences between ALA-treated and untreated Tg2576 mice. Brain levels of nitrotyrosine, a marker of nitrative stress, were elevated in Tg2576 mice, while F2 isoprostanes and neuroprostanes, oxidative stress markers, were not elevated in the Tg2576 mice relative to wild type. These data indicate that chronic dietary ALA can reduce hippocampal-dependent memory deficits of Tg2576 mice without affecting β-amyloid levels or plaque deposition.

AB - Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology. Here, the effects of the antioxidant, α-lipoic acid (ALA) were tested on the Tg2576 mouse, a transgenic model of cerebral amyloidosis associated with AD. Ten-month old Tg2576 and wild type mice were fed an ALA-containing diet (0.1%) or control diet for 6 months and then assessed for the influence of diet on memory and neuropathology. ALA-treated Tg2576 mice exhibited significantly improved learning, and memory retention in the Morris water maze task compared to untreated Tg2576 mice. Twenty-four hours after contextual fear conditioning, untreated Tg2576 mice exhibited significantly impaired context-dependent freezing. ALA-treated Tg2576 mice exhibited significantly more context freezing than the untreated Tg2576 mice. Assessment of brain soluble and insoluble β-amyloid levels revealed no differences between ALA-treated and untreated Tg2576 mice. Brain levels of nitrotyrosine, a marker of nitrative stress, were elevated in Tg2576 mice, while F2 isoprostanes and neuroprostanes, oxidative stress markers, were not elevated in the Tg2576 mice relative to wild type. These data indicate that chronic dietary ALA can reduce hippocampal-dependent memory deficits of Tg2576 mice without affecting β-amyloid levels or plaque deposition.

KW - Alzheimer's disease

KW - Amyloid

KW - Antioxidant

KW - Context memory

KW - Hippocampus

KW - Nitrotyrosine

KW - Spatial memory

UR - http://www.scopus.com/inward/record.url?scp=33845442944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845442944&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2005.12.014

DO - 10.1016/j.neurobiolaging.2005.12.014

M3 - Article

C2 - 16448723

AN - SCOPUS:33845442944

VL - 28

SP - 213

EP - 225

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 2

ER -