Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability

Erich J. Baker, Jonathan Farro, Steven Gonzales, Christa Helms, Kathleen (Kathy) Grant

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    Background: The current criteria for alcohol use disorders (AUDs) do not include consumption (quantity/frequency) measures of alcohol intake, in part due to the difficulty of these measures in humans. Animal models of ethanol (EtOH) self-administration have been fundamental in advancing our understanding of the neurobiological basis of AUD and can address quantity/frequency measures with accurate measurements over prolonged periods of time. The nonhuman primate model of voluntary oral alcohol self-administration has documented both binge drinking and drinking to dependence and can be used to test the stability of consumption measures over time. Methods: Here, an extensive set of alcohol intakes (g/kg/d) was analyzed from a large multi-cohort population of Rhesus (Macaca mulatta) monkeys (n = 31). Daily EtOH intake was uniformly distributed over chronic (12 months) access for all animals. Results: Underlying this distribution of intakes were subpopulations of monkeys that exhibited distinctive clustering of drinking patterns, allowing us to categorically define very heavy drinking (VHD), heavy drinking (HD), binge drinking (BD), and low drinking (LD). These categories were stable across the 12 months assessed by the protocol, but exhibited fluctuations when examined at shorter intervals. Conclusions: The establishment of persistent drinking categories based on quantity/frequency suggests that consumption variables can be used to track long-term changes in behavioral, molecular, or physiochemical mechanisms related to our understanding of diagnosis, prevention, intervention, and treatment efficacies.

    Original languageEnglish (US)
    Pages (from-to)2835-2843
    Number of pages9
    JournalAlcoholism: Clinical and Experimental Research
    Volume38
    Issue number11
    DOIs
    StatePublished - Nov 1 2014

    Fingerprint

    Frequency stability
    Self Administration
    Drinking
    Haplorhini
    Alcohols
    Binge Drinking
    Animals
    Macaca mulatta
    Ethanol
    Primates
    Cluster Analysis
    Animal Models
    Population

    Keywords

    • Alcohol
    • Binge drinking
    • EtOH
    • Nonhuman primates
    • Self-administration

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Psychiatry and Mental health
    • Toxicology
    • Medicine(all)

    Cite this

    Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability. / Baker, Erich J.; Farro, Jonathan; Gonzales, Steven; Helms, Christa; Grant, Kathleen (Kathy).

    In: Alcoholism: Clinical and Experimental Research, Vol. 38, No. 11, 01.11.2014, p. 2835-2843.

    Research output: Contribution to journalArticle

    Baker, Erich J. ; Farro, Jonathan ; Gonzales, Steven ; Helms, Christa ; Grant, Kathleen (Kathy). / Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability. In: Alcoholism: Clinical and Experimental Research. 2014 ; Vol. 38, No. 11. pp. 2835-2843.
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