Chronic Airflow Obstruction in a Black African Population: Results of BOLD Study, Ile-Ife, Nigeria

Daniel O. Obaseki, Gregory E. Erhabor, Louisa Gnatiuc, Olufemi O. Adewole, A (Sonia) Buist, Peter G. Burney

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Global estimates suggest that Chronic Obstructive Pulmonary Disease (COPD) is emerging as a leading cause of death in developing countries but there are few spirometry-based general population data on its prevalence and risk factors in sub-Saharan Africa. We used the Burden of Obstructive Lung Disease (BOLD) protocol to select a representative sample of adults aged 40 years and above in Ile-Ife, Nigeria. All the participants underwent spirometry and provided information on smoking history, biomass and occupational exposures as well as diagnosed respiratory diseases and symptoms. Chronic Airflow Obstruction (CAO) was defined as the ratio of post-bronchodilator (BD) one second Forced Expiratory Volume (FEV1) to Forced Vital Capacity (FVC) below the lower limit of normal (LLN) of the population distribution for FEV1/FVC.The overall prevalence of obstruction (post-BD FEV1/FVC <LLN) was 7.7% (2.7% above LLN) using Global Lung Function Initiative (GLI) equations. It was associated with few respiratory symptoms; 0.3% reported a previous doctor-diagnosed chronic bronchitis, emphysema or COPD. Independent predictors included a lack of education (OR 2·5, 95% CI: 1.0, 6.4) and a diagnosis of either TB (OR 23.4, 95% CI: 2.0, 278.6) or asthma (OR 35.4, 95%CI: 4.9, 255.8). There was no association with the use of firewood or coal for cooking or heating. The vast majority of this population (89%) are never smokers. We conclude that the prevalence of CAO is low in Ile-Ife, Nigeria and unrelated to biomass exposure. The key independent predictors are poor education, and previous diagnosis of tuberculosis or asthma.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Volume13
Issue number1
DOIs
StatePublished - Jan 2 2016

Fingerprint

Obstructive Lung Diseases
Nigeria
Chronic Obstructive Pulmonary Disease
Vital Capacity
Bronchodilator Agents
Spirometry
Biomass
Population
Asthma
Education
Coal
Africa South of the Sahara
Normal Distribution
Chronic Bronchitis
Emphysema
Forced Expiratory Volume
Cooking
Occupational Exposure
Heating
Developing Countries

Keywords

  • CAO
  • COPD
  • Nigeria
  • prevalence
  • spirometry

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Chronic Airflow Obstruction in a Black African Population : Results of BOLD Study, Ile-Ife, Nigeria. / Obaseki, Daniel O.; Erhabor, Gregory E.; Gnatiuc, Louisa; Adewole, Olufemi O.; Buist, A (Sonia); Burney, Peter G.

In: COPD: Journal of Chronic Obstructive Pulmonary Disease, Vol. 13, No. 1, 02.01.2016, p. 42-49.

Research output: Contribution to journalArticle

Obaseki, Daniel O. ; Erhabor, Gregory E. ; Gnatiuc, Louisa ; Adewole, Olufemi O. ; Buist, A (Sonia) ; Burney, Peter G. / Chronic Airflow Obstruction in a Black African Population : Results of BOLD Study, Ile-Ife, Nigeria. In: COPD: Journal of Chronic Obstructive Pulmonary Disease. 2016 ; Vol. 13, No. 1. pp. 42-49.
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