Chronic airflow obstruction and markers of systemic inflammation: Results from the BOLD study in Iceland

Sigurdur James Thorleifsson, Olof Birna Margretardottir, Gunnar Gudmundsson, Isleifur Olafsson, Bryndis Benediktsdottir, Christer Janson, A (Sonia) Buist, Thorarinn Gislason

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible chronic airflow obstruction and by an accelerated decline in lung function. Elevated circulating levels of C-reactive protein (CRP) and interleukin-6 (IL-6), both markers of systemic inflammation, have been found in COPD. Their possible associations with chronic airflow obstruction have mostly been evaluated in highly selected patient samples. Our objective was to evaluate the association between postbronchodilator lung function CRP and IL-6 in a randomly selected sample of the Icelandic population, 40 years and older, while adjusting for gender, age, smoking, and body weight. Methods: Serum CRP and IL-6 values were measured among participants in the Burden of Obstructive Lung Disease (BOLD) study. Results: Of the 938 subjects invited a total of 403 men and 355 women participated (response rate 81%) in the study. Their mean age (±SD) was 57.7 (±12.7) years. Both CRP and IL-6 were independently related to lower FEV1 and FVC values. Individuals in the highest quartiles of CRP and IL-6 had a 7.5% and 3.9%, respectively, lower FEV1% than predicted after adjustment for smoking, age, and body weight. High CRP levels were more strongly related to lower FEV1 levels in men (-11.4%) than in women (-0.4%). Conclusions: In a random population-based sample both CRP and IL-6 were significantly related to lower spirometric values. The association with CRP was stronger in men than in women. This finding underscores the possible importance of systemic inflammation in irreversible airflow limitation.

Original languageEnglish (US)
Pages (from-to)1548-1553
Number of pages6
JournalRespiratory Medicine
Volume103
Issue number10
DOIs
StatePublished - Oct 2009

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Obstructive Lung Diseases
Iceland
C-Reactive Protein
Chronic Obstructive Pulmonary Disease
Inflammation
Interleukin-6
Smoking
Body Weight
Lung
Population
Blood Proteins

Keywords

  • Airflow obstruction
  • C-reactive protein
  • Cytokines
  • IL-6
  • Systemic inflammation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Thorleifsson, S. J., Margretardottir, O. B., Gudmundsson, G., Olafsson, I., Benediktsdottir, B., Janson, C., ... Gislason, T. (2009). Chronic airflow obstruction and markers of systemic inflammation: Results from the BOLD study in Iceland. Respiratory Medicine, 103(10), 1548-1553. https://doi.org/10.1016/j.rmed.2009.04.005

Chronic airflow obstruction and markers of systemic inflammation : Results from the BOLD study in Iceland. / Thorleifsson, Sigurdur James; Margretardottir, Olof Birna; Gudmundsson, Gunnar; Olafsson, Isleifur; Benediktsdottir, Bryndis; Janson, Christer; Buist, A (Sonia); Gislason, Thorarinn.

In: Respiratory Medicine, Vol. 103, No. 10, 10.2009, p. 1548-1553.

Research output: Contribution to journalArticle

Thorleifsson, SJ, Margretardottir, OB, Gudmundsson, G, Olafsson, I, Benediktsdottir, B, Janson, C, Buist, AS & Gislason, T 2009, 'Chronic airflow obstruction and markers of systemic inflammation: Results from the BOLD study in Iceland', Respiratory Medicine, vol. 103, no. 10, pp. 1548-1553. https://doi.org/10.1016/j.rmed.2009.04.005
Thorleifsson SJ, Margretardottir OB, Gudmundsson G, Olafsson I, Benediktsdottir B, Janson C et al. Chronic airflow obstruction and markers of systemic inflammation: Results from the BOLD study in Iceland. Respiratory Medicine. 2009 Oct;103(10):1548-1553. https://doi.org/10.1016/j.rmed.2009.04.005
Thorleifsson, Sigurdur James ; Margretardottir, Olof Birna ; Gudmundsson, Gunnar ; Olafsson, Isleifur ; Benediktsdottir, Bryndis ; Janson, Christer ; Buist, A (Sonia) ; Gislason, Thorarinn. / Chronic airflow obstruction and markers of systemic inflammation : Results from the BOLD study in Iceland. In: Respiratory Medicine. 2009 ; Vol. 103, No. 10. pp. 1548-1553.
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abstract = "Background: Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible chronic airflow obstruction and by an accelerated decline in lung function. Elevated circulating levels of C-reactive protein (CRP) and interleukin-6 (IL-6), both markers of systemic inflammation, have been found in COPD. Their possible associations with chronic airflow obstruction have mostly been evaluated in highly selected patient samples. Our objective was to evaluate the association between postbronchodilator lung function CRP and IL-6 in a randomly selected sample of the Icelandic population, 40 years and older, while adjusting for gender, age, smoking, and body weight. Methods: Serum CRP and IL-6 values were measured among participants in the Burden of Obstructive Lung Disease (BOLD) study. Results: Of the 938 subjects invited a total of 403 men and 355 women participated (response rate 81{\%}) in the study. Their mean age (±SD) was 57.7 (±12.7) years. Both CRP and IL-6 were independently related to lower FEV1 and FVC values. Individuals in the highest quartiles of CRP and IL-6 had a 7.5{\%} and 3.9{\%}, respectively, lower FEV1{\%} than predicted after adjustment for smoking, age, and body weight. High CRP levels were more strongly related to lower FEV1 levels in men (-11.4{\%}) than in women (-0.4{\%}). Conclusions: In a random population-based sample both CRP and IL-6 were significantly related to lower spirometric values. The association with CRP was stronger in men than in women. This finding underscores the possible importance of systemic inflammation in irreversible airflow limitation.",
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T2 - Results from the BOLD study in Iceland

AU - Thorleifsson, Sigurdur James

AU - Margretardottir, Olof Birna

AU - Gudmundsson, Gunnar

AU - Olafsson, Isleifur

AU - Benediktsdottir, Bryndis

AU - Janson, Christer

AU - Buist, A (Sonia)

AU - Gislason, Thorarinn

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N2 - Background: Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible chronic airflow obstruction and by an accelerated decline in lung function. Elevated circulating levels of C-reactive protein (CRP) and interleukin-6 (IL-6), both markers of systemic inflammation, have been found in COPD. Their possible associations with chronic airflow obstruction have mostly been evaluated in highly selected patient samples. Our objective was to evaluate the association between postbronchodilator lung function CRP and IL-6 in a randomly selected sample of the Icelandic population, 40 years and older, while adjusting for gender, age, smoking, and body weight. Methods: Serum CRP and IL-6 values were measured among participants in the Burden of Obstructive Lung Disease (BOLD) study. Results: Of the 938 subjects invited a total of 403 men and 355 women participated (response rate 81%) in the study. Their mean age (±SD) was 57.7 (±12.7) years. Both CRP and IL-6 were independently related to lower FEV1 and FVC values. Individuals in the highest quartiles of CRP and IL-6 had a 7.5% and 3.9%, respectively, lower FEV1% than predicted after adjustment for smoking, age, and body weight. High CRP levels were more strongly related to lower FEV1 levels in men (-11.4%) than in women (-0.4%). Conclusions: In a random population-based sample both CRP and IL-6 were significantly related to lower spirometric values. The association with CRP was stronger in men than in women. This finding underscores the possible importance of systemic inflammation in irreversible airflow limitation.

AB - Background: Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible chronic airflow obstruction and by an accelerated decline in lung function. Elevated circulating levels of C-reactive protein (CRP) and interleukin-6 (IL-6), both markers of systemic inflammation, have been found in COPD. Their possible associations with chronic airflow obstruction have mostly been evaluated in highly selected patient samples. Our objective was to evaluate the association between postbronchodilator lung function CRP and IL-6 in a randomly selected sample of the Icelandic population, 40 years and older, while adjusting for gender, age, smoking, and body weight. Methods: Serum CRP and IL-6 values were measured among participants in the Burden of Obstructive Lung Disease (BOLD) study. Results: Of the 938 subjects invited a total of 403 men and 355 women participated (response rate 81%) in the study. Their mean age (±SD) was 57.7 (±12.7) years. Both CRP and IL-6 were independently related to lower FEV1 and FVC values. Individuals in the highest quartiles of CRP and IL-6 had a 7.5% and 3.9%, respectively, lower FEV1% than predicted after adjustment for smoking, age, and body weight. High CRP levels were more strongly related to lower FEV1 levels in men (-11.4%) than in women (-0.4%). Conclusions: In a random population-based sample both CRP and IL-6 were significantly related to lower spirometric values. The association with CRP was stronger in men than in women. This finding underscores the possible importance of systemic inflammation in irreversible airflow limitation.

KW - Airflow obstruction

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KW - Cytokines

KW - IL-6

KW - Systemic inflammation

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