Chromosome abnormalities of eighty-one pediatric germ cell tumors: Sex- , age-, site-, and histopathology-related differences - A children's cancer group study

Kimberly J. Bussey, Helen J. Lawce, Susan Olson, Diane C. Arthur, Dagmar K. Kalousek, Mark Krailo, Roger Giller, Stephen Heifetz, Rick Womer, R. Ellen Magenis

Research output: Contribution to journalArticle

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Abstract

The chromosomes of 81 pediatric germ cell tumors (GCTs) were analyzed as part of two clinical treatment trials, INT-0098 and INT-0097, conducted by the Children's Cancer Group. The analysis of chromosome results showed differences with respect to sex, age, tumor location, and histology. Sixteen of 17 benign teratomas of infants and children less than 4 years old and from gonadal and extragonadal locations were chromosomally normal. Twenty-three malignant GCTs from gonadal and extragonadal locations of the same age group were endodermal sinus tumors and varied in their karyotypic findings. The most common abnormalities were gains of 1q and chromosome 3. Of eight benign ovarian teratomas from older girls, five with normal G-banded karyotypes were determined to be homozygous for Q-band heteromorphisms, suggesting a meiosis II error. Among the 12 malignant ovarian GCTs from older girls, the common abnormalities were loss of I p/gain of 1q, + 3, +8, + 14, and + 21. Four of eight extragonadal tumors from older boys demonstrated +21; one had +X. Five of the eight had associated constitutional chromosome abnormalities, including one trisomy 21 and three with Klinefelter syndrome. The testicular GCTs of adolescents had abnormalities resembling those found in adult testicular GCT, including near-triploidy, loss of chromosomes 11, 13, and 18, and gain of chromosomes 7, 8, the X chromosome, and an isochromosome 12p. The gain of an isochromosome 12p was only frequent in the tumors from adolescent boys. Deletion of 1p/gain of 1q and +3 were the most common abnormalities among the malignant tumors from both sexes.

Original languageEnglish (US)
Pages (from-to)134-146
Number of pages13
JournalGenes Chromosomes and Cancer
Volume25
Issue number2
DOIs
StatePublished - Jun 1999

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Germ Cell and Embryonal Neoplasms
Chromosome Aberrations
Pediatrics
Isochromosomes
Teratoma
Neoplasms
Chromosomes
Endodermal Sinus Tumor
Klinefelter Syndrome
Chromosomes, Human, Pair 18
Triploidy
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 7
Meiosis
X Chromosome
Down Syndrome
Karyotype

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Chromosome abnormalities of eighty-one pediatric germ cell tumors : Sex- , age-, site-, and histopathology-related differences - A children's cancer group study. / Bussey, Kimberly J.; Lawce, Helen J.; Olson, Susan; Arthur, Diane C.; Kalousek, Dagmar K.; Krailo, Mark; Giller, Roger; Heifetz, Stephen; Womer, Rick; Magenis, R. Ellen.

In: Genes Chromosomes and Cancer, Vol. 25, No. 2, 06.1999, p. 134-146.

Research output: Contribution to journalArticle

Bussey, Kimberly J. ; Lawce, Helen J. ; Olson, Susan ; Arthur, Diane C. ; Kalousek, Dagmar K. ; Krailo, Mark ; Giller, Roger ; Heifetz, Stephen ; Womer, Rick ; Magenis, R. Ellen. / Chromosome abnormalities of eighty-one pediatric germ cell tumors : Sex- , age-, site-, and histopathology-related differences - A children's cancer group study. In: Genes Chromosomes and Cancer. 1999 ; Vol. 25, No. 2. pp. 134-146.
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AU - Olson, Susan

AU - Arthur, Diane C.

AU - Kalousek, Dagmar K.

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AU - Womer, Rick

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