Chromosome aberrations in solid tumors

Donna G. Albertson, Colin Collins, Frank McCormick, Joe Gray

Research output: Contribution to journalArticle

563 Scopus citations

Abstract

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalNature Genetics
Volume34
Issue number4
DOIs
Publication statusPublished - Aug 1 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Albertson, D. G., Collins, C., McCormick, F., & Gray, J. (2003). Chromosome aberrations in solid tumors. Nature Genetics, 34(4), 369-376. https://doi.org/10.1038/ng1215