Chromosome aberrations in solid tumors

Donna G. Albertson; Colin Collins; Frank McCormick; Joe W. Gray

doi:10.1038/ng1215

Chromosome aberrations in solid tumors

Donna G. Albertson, Colin Collins, Frank McCormick, Joe W. Gray

Research output: Contribution to journal › Review article › peer-review

644 Scopus citations

Abstract

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

Original language	English (US)
Pages (from-to)	369-376
Number of pages	8
Journal	Nature genetics
Volume	34
Issue number	4
DOIs	https://doi.org/10.1038/ng1215
State	Published - Aug 1 2003
Externally published	Yes

ASJC Scopus subject areas

Genetics

Access to Document

10.1038/ng1215

Cite this

@article{0bd0061dcbe148a9abcb2e34686c69ce,

title = "Chromosome aberrations in solid tumors",

abstract = "Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.",

author = "Albertson, {Donna G.} and Colin Collins and Frank McCormick and Gray, {Joe W.}",

note = "Funding Information: This work was supported by the United States Public Health Service and the Avon Foundation.",

year = "2003",

month = aug,

day = "1",

doi = "10.1038/ng1215",

language = "English (US)",

volume = "34",

pages = "369--376",

journal = "Nature genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Chromosome aberrations in solid tumors

AU - Albertson, Donna G.

AU - Collins, Colin

AU - McCormick, Frank

AU - Gray, Joe W.

N1 - Funding Information: This work was supported by the United States Public Health Service and the Avon Foundation.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

AB - Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

UR - http://www.scopus.com/inward/record.url?scp=0042166174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042166174&partnerID=8YFLogxK

U2 - 10.1038/ng1215

DO - 10.1038/ng1215

M3 - Review article

C2 - 12923544

AN - SCOPUS:0042166174

SN - 1061-4036

VL - 34

SP - 369

EP - 376

JO - Nature genetics

JF - Nature genetics

IS - 4

ER -

Chromosome aberrations in solid tumors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this