Chromosome aberrations in solid tumors

Donna G. Albertson, Colin Collins, Frank McCormick, Joe W. Gray

Research output: Contribution to journalReview article

583 Scopus citations

Abstract

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalNature genetics
Volume34
Issue number4
DOIs
StatePublished - Aug 1 2003

ASJC Scopus subject areas

  • Genetics

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