Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma

Jeffrey La Rochelle, Tobias Klatte, Aditi Dastane, Nagesh Rao, David Seligson, Jonathan Said, Brian Shuch, Nazy Zomorodian, Fairooz Kabbinavar, Arie Belldegrun, Allan J. Pantuck

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

BACKGROUND: The authors investigated whether deletion of chromosome 9p in clear cell renal cell carcinoma (ccRCC) predicted worse disease-specific survival (DSS) and recurrence-free survival (RFS) and whether it was associated with more aggressive behavior in small renal masses. METHODS: In total, 703 ccRCC tumors were analyzed using fluorescence in situ hybridization (316 tumors) and cytogenetics (388 tumors). Tumor grade, classification, and size; 9p status; Eastern Cooperative Oncology Group performance status (ECOG PS); lymph node involvement; and the presence of metastasis were recorded. Outcomes were stratified by 9p status, and a Cox proportional hazards models was constructed using TNM staging, ECOG PS, tumor size, tumor grade, and 9p status. RESULTS: Deletions of 9p were detected in 97 tumors (13.8%). At presentation, 9p-deleted tumors were larger and were more likely to be high grade (grade 3 or 4), to have a high tumor (T) classification (T3-T4), and to have lymph node or distant metastases (P

Original languageEnglish (US)
Pages (from-to)4696-4702
Number of pages7
JournalCancer
Volume116
Issue number20
DOIs
StatePublished - 2010
Externally publishedYes

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Chromosome Deletion
Renal Cell Carcinoma
Phenotype
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Neoplasm Staging
Fluorescence In Situ Hybridization
Proportional Hazards Models
Cytogenetics
Kidney
Recurrence

Keywords

  • Biomarkers
  • Chromosome 9p
  • Kidney cancer
  • Prognosis
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

La Rochelle, J., Klatte, T., Dastane, A., Rao, N., Seligson, D., Said, J., ... Pantuck, A. J. (2010). Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma. Cancer, 116(20), 4696-4702. https://doi.org/10.1002/cncr.25279

Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma. / La Rochelle, Jeffrey; Klatte, Tobias; Dastane, Aditi; Rao, Nagesh; Seligson, David; Said, Jonathan; Shuch, Brian; Zomorodian, Nazy; Kabbinavar, Fairooz; Belldegrun, Arie; Pantuck, Allan J.

In: Cancer, Vol. 116, No. 20, 2010, p. 4696-4702.

Research output: Contribution to journalArticle

La Rochelle, J, Klatte, T, Dastane, A, Rao, N, Seligson, D, Said, J, Shuch, B, Zomorodian, N, Kabbinavar, F, Belldegrun, A & Pantuck, AJ 2010, 'Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma', Cancer, vol. 116, no. 20, pp. 4696-4702. https://doi.org/10.1002/cncr.25279
La Rochelle J, Klatte T, Dastane A, Rao N, Seligson D, Said J et al. Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma. Cancer. 2010;116(20):4696-4702. https://doi.org/10.1002/cncr.25279
La Rochelle, Jeffrey ; Klatte, Tobias ; Dastane, Aditi ; Rao, Nagesh ; Seligson, David ; Said, Jonathan ; Shuch, Brian ; Zomorodian, Nazy ; Kabbinavar, Fairooz ; Belldegrun, Arie ; Pantuck, Allan J. / Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma. In: Cancer. 2010 ; Vol. 116, No. 20. pp. 4696-4702.
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AU - La Rochelle, Jeffrey

AU - Klatte, Tobias

AU - Dastane, Aditi

AU - Rao, Nagesh

AU - Seligson, David

AU - Said, Jonathan

AU - Shuch, Brian

AU - Zomorodian, Nazy

AU - Kabbinavar, Fairooz

AU - Belldegrun, Arie

AU - Pantuck, Allan J.

PY - 2010

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N2 - BACKGROUND: The authors investigated whether deletion of chromosome 9p in clear cell renal cell carcinoma (ccRCC) predicted worse disease-specific survival (DSS) and recurrence-free survival (RFS) and whether it was associated with more aggressive behavior in small renal masses. METHODS: In total, 703 ccRCC tumors were analyzed using fluorescence in situ hybridization (316 tumors) and cytogenetics (388 tumors). Tumor grade, classification, and size; 9p status; Eastern Cooperative Oncology Group performance status (ECOG PS); lymph node involvement; and the presence of metastasis were recorded. Outcomes were stratified by 9p status, and a Cox proportional hazards models was constructed using TNM staging, ECOG PS, tumor size, tumor grade, and 9p status. RESULTS: Deletions of 9p were detected in 97 tumors (13.8%). At presentation, 9p-deleted tumors were larger and were more likely to be high grade (grade 3 or 4), to have a high tumor (T) classification (T3-T4), and to have lymph node or distant metastases (P

AB - BACKGROUND: The authors investigated whether deletion of chromosome 9p in clear cell renal cell carcinoma (ccRCC) predicted worse disease-specific survival (DSS) and recurrence-free survival (RFS) and whether it was associated with more aggressive behavior in small renal masses. METHODS: In total, 703 ccRCC tumors were analyzed using fluorescence in situ hybridization (316 tumors) and cytogenetics (388 tumors). Tumor grade, classification, and size; 9p status; Eastern Cooperative Oncology Group performance status (ECOG PS); lymph node involvement; and the presence of metastasis were recorded. Outcomes were stratified by 9p status, and a Cox proportional hazards models was constructed using TNM staging, ECOG PS, tumor size, tumor grade, and 9p status. RESULTS: Deletions of 9p were detected in 97 tumors (13.8%). At presentation, 9p-deleted tumors were larger and were more likely to be high grade (grade 3 or 4), to have a high tumor (T) classification (T3-T4), and to have lymph node or distant metastases (P

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KW - Prognosis

KW - Renal cell carcinoma

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