Chromosomal localization of three human D5 dopamine receptor genes

David K. Grandy, Lee J. Allen, Yuan Zhang, R. Ellen Magenis, Olivier Civelli

    Research output: Contribution to journalArticle

    34 Scopus citations

    Abstract

    It is currently thought that genetic predisposition to imbalances in dopaminergic transmission may underlie several neurological disorders, including schizophrenia, manic depression, Tourette syndrome, Parkinson disease, Huntington disease, and alcohol abuse. Originally two receptors, D1 and D2, were thought to account for all of the pharmacological actions of dopamine. However, through homology screening three additional genes, D3, D4, and D5, and two pseudogenes closely related to D5 have been characterized. To begin our genomic and evolutionary analyses of the human D5 dopamine receptor gene and its two pseudogenes, we have mapped each of them to their respective chromosomes. By combining in situ hybridization results with sequence analysis of PCR products from microdissected chromosomes, somatic cell hybrids, and radiation hybrids, we have assigned DRD5 (the locus containing the functional human D5 receptor gene) to chromosome 4p16.1, DRD5P1 (the locus containing D5 pseudogene 1) to chromosome 2p11.1-p11.2, and DRD5P2 (the locus of D5 pseudogene 2) to chromosome 1q21.1.

    Original languageEnglish (US)
    Pages (from-to)968-973
    Number of pages6
    JournalGenomics
    Volume13
    Issue number4
    DOIs
    StatePublished - Aug 1992

    ASJC Scopus subject areas

    • Genetics

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  • Cite this

    Grandy, D. K., Allen, L. J., Zhang, Y., Magenis, R. E., & Civelli, O. (1992). Chromosomal localization of three human D5 dopamine receptor genes. Genomics, 13(4), 968-973. https://doi.org/10.1016/0888-7543(92)90009-H