We have used two complementary approaches to analyze the chromosomal location of the γ-glutamyl carboxylase gene. The amplification of a carboxylase-specific genomic fragment by polymerase chain reaction (PCR) in a human-rodent hybrid cell mapping panel localized the gene to chromosome 2. Mapping by fluorescence in situ hybridization assigned the gene to p12 of chromosome 2. Our results indicate that the γ-glutamyl carboxylase gene has a single locus in the human genome.
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