Chromosomal localization of the γ-glutamyl carboxylase gene at 2p12

Wen Lin Kuo; Darrel W. Stafford; Jesús Cruces; Joe Gray; Solera Jesú

doi:10.1016/0888-7543(95)80024-G

Chromosomal localization of the γ-glutamyl carboxylase gene at 2p12

Wen Lin Kuo, Darrel W. Stafford, Jesús Cruces, Joe Gray, Solera Jesú

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

We have used two complementary approaches to analyze the chromosomal location of the γ-glutamyl carboxylase gene. The amplification of a carboxylase-specific genomic fragment by polymerase chain reaction (PCR) in a human-rodent hybrid cell mapping panel localized the gene to chromosome 2. Mapping by fluorescence in situ hybridization assigned the gene to p12 of chromosome 2. Our results indicate that the γ-glutamyl carboxylase gene has a single locus in the human genome.

Original language	English (US)
Pages (from-to)	746-748
Number of pages	3
Journal	Genomics
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(95)80024-G
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Chromosomal localization of the γ-glutamyl carboxylase gene at 2p12",

abstract = "We have used two complementary approaches to analyze the chromosomal location of the γ-glutamyl carboxylase gene. The amplification of a carboxylase-specific genomic fragment by polymerase chain reaction (PCR) in a human-rodent hybrid cell mapping panel localized the gene to chromosome 2. Mapping by fluorescence in situ hybridization assigned the gene to p12 of chromosome 2. Our results indicate that the γ-glutamyl carboxylase gene has a single locus in the human genome.",

author = "Kuo, {Wen Lin} and Stafford, {Darrel W.} and Jes{\'u}s Cruces and Joe Gray and Solera Jes{\'u}",

note = "Funding Information: This work was supported by NIH Grants HL38973 and HL06350, by grants from Fondo de Investigation Sanitaria, Spain, and by Imaginetics, Inc. (Framingham, MA).",

year = "1995",

doi = "10.1016/0888-7543(95)80024-G",

language = "English (US)",

volume = "25",

pages = "746--748",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

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T1 - Chromosomal localization of the γ-glutamyl carboxylase gene at 2p12

AU - Kuo, Wen Lin

AU - Stafford, Darrel W.

AU - Cruces, Jesús

AU - Gray, Joe

AU - Jesú, Solera

N1 - Funding Information: This work was supported by NIH Grants HL38973 and HL06350, by grants from Fondo de Investigation Sanitaria, Spain, and by Imaginetics, Inc. (Framingham, MA).

PY - 1995

Y1 - 1995

N2 - We have used two complementary approaches to analyze the chromosomal location of the γ-glutamyl carboxylase gene. The amplification of a carboxylase-specific genomic fragment by polymerase chain reaction (PCR) in a human-rodent hybrid cell mapping panel localized the gene to chromosome 2. Mapping by fluorescence in situ hybridization assigned the gene to p12 of chromosome 2. Our results indicate that the γ-glutamyl carboxylase gene has a single locus in the human genome.

AB - We have used two complementary approaches to analyze the chromosomal location of the γ-glutamyl carboxylase gene. The amplification of a carboxylase-specific genomic fragment by polymerase chain reaction (PCR) in a human-rodent hybrid cell mapping panel localized the gene to chromosome 2. Mapping by fluorescence in situ hybridization assigned the gene to p12 of chromosome 2. Our results indicate that the γ-glutamyl carboxylase gene has a single locus in the human genome.

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JO - Genomics

JF - Genomics

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ER -

Chromosomal localization of the γ-glutamyl carboxylase gene at 2p12

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