Abstract
Purpose: To report a rare case of central vision loss in a patient with choroideremia.
Patients and methods: A retrospective, interventional case report.
Results: A 13-year-old male with history of choroideremia presented with subacute loss of central acuity in his left eye. Examination and diagnostic testing revealed subretinal fibrosis secondary to a choroidal neovascular membrane (CNVM). A trial of anti-vascular endothelial growth factor (VEGF) therapy with the injection of intravitreal bevacizumab was attempted. Mild improvements in acuity and anatomy were noted.
Conclusion: Choroideremia is a rare hereditary choroidal dystrophy that predominantly affects males in the first and second decades of life. Visual acuity is usually spared until later in life. CNVM is a rare manifestation of choroideremia with only a handful of case reports presented in the literature. This case is unique in that it is the first reported case that received treatment with intravitreal anti-VEGF therapy.
Original language | English (US) |
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Pages (from-to) | 1675-1679 |
Number of pages | 5 |
Journal | Clinical Ophthalmology |
Volume | 8 |
DOIs | |
State | Published - Sep 1 2014 |
Keywords
- Anti-VEGF therapy
- Chorioretinal degeneration
- Choroidal neovascular membrane
- Choroideremia
- Hereditary choroidal dystrophy
- Intravitreal bevacizumab injection
ASJC Scopus subject areas
- Ophthalmology