Choroidal ganglioneuroma in neurofibromatosis

J. J. Woog, D. M. Albert, J. Craft, N. Silberman, D. Horns

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

A twenty-one year old female with previously unsuspected neurofibromatosis presented for evaluation of a blind painful eye. Histopathologic examination of the enucleated specimen revealed choroidal thickening with ovoid bodies and proliferation of connective tissue with pigment-containing cells and ganglion-like cells. Electron microscopic study of the latter cell population revealed typical morphologic features of ganglion cells, including numerous electron-dense intracellular granules and an abundance of mitochondria and rough endoplasmic reticulum. These pathologic findings were interpreted as consistent with the diagnosis of choroidal ganglioneuroma occurring in the context of ocular neurofibromatosis. The literature concerning this unusual tumor is reviewed and the possible relationship of this lesion to neurofibromatosis and other disorders of neural cresent proliferation are briefly discussed.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume220
Issue number1
DOIs
StatePublished - Jan 1983

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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