Choroidal ganglioneuroma in neurofibromatosis

J. J. Woog, D. M. Albert, J. Craft, N. Silberman, D. Horns

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A twenty-one year old female with previously unsuspected neurofibromatosis presented for evaluation of a blind painful eye. Histopathologic examination of the enucleated specimen revealed choroidal thickening with ovoid bodies and proliferation of connective tissue with pigment-containing cells and ganglion-like cells. Electron microscopic study of the latter cell population revealed typical morphologic features of ganglion cells, including numerous electron-dense intracellular granules and an abundance of mitochondria and rough endoplasmic reticulum. These pathologic findings were interpreted as consistent with the diagnosis of choroidal ganglioneuroma occurring in the context of ocular neurofibromatosis. The literature concerning this unusual tumor is reviewed and the possible relationship of this lesion to neurofibromatosis and other disorders of neural cresent proliferation are briefly discussed.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number1
StatePublished - Jan 1983
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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