Chorionic villus sampling: First-trimester prenatal diagnosis of partial 10q trisomy in a family with a 4 10 translocation

Susan Olson, R. Ellen Magenis, John G. Buckmaster, John M. Bissonnette

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Direct chromosome preparations of cells obtained through chorionic villus sampling at 8 weeks' gestation in a patient whose spouse is a balanced translocation carrier revealed a fetus with an unbalanced karyotype. Knowledge of the abnormality allowed the family to make a decision in regard to continuation of the pregnancy earlier than would have been possible with the routine procedure of amniocentesis. Although the risks of chorionic villus sampling are currently being investigated, it appears that this technique has great potential for early diagnosis, affording psychological advantages, as well as a safer termination in the event of an abnormal fetus.

Original languageEnglish (US)
Pages (from-to)743-744
Number of pages2
JournalAmerican Journal of Obstetrics and Gynecology
Volume153
Issue number7
DOIs
StatePublished - Dec 1 1985

Fingerprint

Chorionic Villi Sampling
First Pregnancy Trimester
Prenatal Diagnosis
Fetus
Pregnancy
Amniocentesis
Spouses
Karyotype
Early Diagnosis
Chromosomes
Psychology
Chromosome 10q duplication syndrome

Keywords

  • Chorionic villus sampling
  • prenatal diagnosis

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Chorionic villus sampling : First-trimester prenatal diagnosis of partial 10q trisomy in a family with a 4 10 translocation. / Olson, Susan; Magenis, R. Ellen; Buckmaster, John G.; Bissonnette, John M.

In: American Journal of Obstetrics and Gynecology, Vol. 153, No. 7, 01.12.1985, p. 743-744.

Research output: Contribution to journalArticle

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