TY - JOUR
T1 - Choriodecidual inflammation
T2 - A harbinger of the preterm labor syndrome
AU - Grigsby, Peta L.
AU - Novy, Miles J.
AU - Waldorf, Kristina M.Adams
AU - Sadowsky, Drew W.
AU - Gravett, Michael G.
PY - 2010/1
Y1 - 2010/1
N2 - Causal, cellular, and inflammatory links between choriodecidual infection with group B streptococcus (GBS) and preterm labor were assessed in a nonhuman primate model. Rhesus monkeys received varying doses of a clinical isolate of GBS, type III or saline, via an indwelling catheter placed between the chorion/decidua and myometrium in the lower pole of the uterus. Choriodecidual inoculation of GBS was followed by a graded response in amniotic fluid (AF) leukocytes, proinflammatory cytokines, prostaglandin E2 and F 2±, and uterine activity (P <.05). The magnitude of the inflammatory response in AF was related, in part, to the initial inoculum size and whether AF cultures remained negative or became positive for GBS. Microbial invasion of AF was associated with advanced inflammation and preterm labor. We provide experimental evidence that choriodeciduitis is a transitional stage of intrauterine infection, which may be self-limited, remain dormant, or progress to intraamniotic infection. These data, coupled with clinical observations, suggest that choriodecidual inflammation is an antecedent event in the pathogenesis of premature cervical ripening (functional cervical insufficiency), premature rupture of the fetal membranes, or preterm labor.
AB - Causal, cellular, and inflammatory links between choriodecidual infection with group B streptococcus (GBS) and preterm labor were assessed in a nonhuman primate model. Rhesus monkeys received varying doses of a clinical isolate of GBS, type III or saline, via an indwelling catheter placed between the chorion/decidua and myometrium in the lower pole of the uterus. Choriodecidual inoculation of GBS was followed by a graded response in amniotic fluid (AF) leukocytes, proinflammatory cytokines, prostaglandin E2 and F 2±, and uterine activity (P <.05). The magnitude of the inflammatory response in AF was related, in part, to the initial inoculum size and whether AF cultures remained negative or became positive for GBS. Microbial invasion of AF was associated with advanced inflammation and preterm labor. We provide experimental evidence that choriodeciduitis is a transitional stage of intrauterine infection, which may be self-limited, remain dormant, or progress to intraamniotic infection. These data, coupled with clinical observations, suggest that choriodecidual inflammation is an antecedent event in the pathogenesis of premature cervical ripening (functional cervical insufficiency), premature rupture of the fetal membranes, or preterm labor.
KW - Choriodecidual inflammation
KW - Group B streptococcus.
KW - Preterm labor
KW - Rhesus monkey
UR - http://www.scopus.com/inward/record.url?scp=77449118192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77449118192&partnerID=8YFLogxK
U2 - 10.1177/1933719109348025
DO - 10.1177/1933719109348025
M3 - Article
C2 - 19843879
AN - SCOPUS:77449118192
SN - 1933-7191
VL - 17
SP - 85
EP - 94
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 1
ER -