Choriodecidual inflammation

A harbinger of the preterm labor syndrome

Peta Grigsby, Miles J. Novy, Kristina M Adams Waldorf, Drew W. Sadowsky, Michael G. Gravett

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    Causal, cellular, and inflammatory links between choriodecidual infection with group B streptococcus (GBS) and preterm labor were assessed in a nonhuman primate model. Rhesus monkeys received varying doses of a clinical isolate of GBS, type III or saline, via an indwelling catheter placed between the chorion/decidua and myometrium in the lower pole of the uterus. Choriodecidual inoculation of GBS was followed by a graded response in amniotic fluid (AF) leukocytes, proinflammatory cytokines, prostaglandin E2 and F , and uterine activity (P

    Original languageEnglish (US)
    Pages (from-to)85-94
    Number of pages10
    JournalReproductive Sciences
    Volume17
    Issue number1
    DOIs
    StatePublished - Jan 2010

    Fingerprint

    Streptococcus agalactiae
    Premature Obstetric Labor
    Inflammation
    Chorion
    Decidua
    Indwelling Catheters
    Myometrium
    Prostaglandins F
    Amniotic Fluid
    Macaca mulatta
    Dinoprostone
    Primates
    Uterus
    Leukocytes
    Cytokines
    Infection

    Keywords

    • Choriodecidual inflammation
    • Group B streptococcus.
    • Preterm labor
    • Rhesus monkey

    ASJC Scopus subject areas

    • Obstetrics and Gynecology
    • Medicine(all)

    Cite this

    Grigsby, P., Novy, M. J., Waldorf, K. M. A., Sadowsky, D. W., & Gravett, M. G. (2010). Choriodecidual inflammation: A harbinger of the preterm labor syndrome. Reproductive Sciences, 17(1), 85-94. https://doi.org/10.1177/1933719109348025

    Choriodecidual inflammation : A harbinger of the preterm labor syndrome. / Grigsby, Peta; Novy, Miles J.; Waldorf, Kristina M Adams; Sadowsky, Drew W.; Gravett, Michael G.

    In: Reproductive Sciences, Vol. 17, No. 1, 01.2010, p. 85-94.

    Research output: Contribution to journalArticle

    Grigsby, P, Novy, MJ, Waldorf, KMA, Sadowsky, DW & Gravett, MG 2010, 'Choriodecidual inflammation: A harbinger of the preterm labor syndrome', Reproductive Sciences, vol. 17, no. 1, pp. 85-94. https://doi.org/10.1177/1933719109348025
    Grigsby, Peta ; Novy, Miles J. ; Waldorf, Kristina M Adams ; Sadowsky, Drew W. ; Gravett, Michael G. / Choriodecidual inflammation : A harbinger of the preterm labor syndrome. In: Reproductive Sciences. 2010 ; Vol. 17, No. 1. pp. 85-94.
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