Cholinergic targets in lung cancer

    Research output: Contribution to journalArticle

    14 Scopus citations

    Abstract

    Lung cancers express an autocrine cholinergic loop in which secreted acetylcholine can stimulate tumor growth through both nicotinic and muscarinic receptors. Because activation of mAChR and nAChR stimulates growth; tumor growth can be stimulated by both locally synthesized acetylcholine as well as acetylcholine from distal sources and from nicotine in the high percentage of lung cancer patients who are smokers. The stimulation of lung cancer growth by cholinergic agonists offers many potential new targets for lung cancer therapy. Cholinergic signaling can be targeted at the level of choline transport; acetylcholine synthesis, secretion and degradation; and nicotinic and muscarinic receptors. In addition, the newly describe family of ly-6 allosteric modulators of nicotinic signaling such as lynx1 and lynx2 offers yet another new approach to novel lung cancer therapeutics. Each of these targets has their potential advantages and disadvantages for the development of new lung cancer therapies which are discussed in this review.

    Original languageEnglish (US)
    Pages (from-to)2152-2159
    Number of pages8
    JournalCurrent Pharmaceutical Design
    Volume22
    Issue number14
    DOIs
    StatePublished - Apr 1 2016

    Keywords

    • Acetylcholine
    • Cancer
    • Lynx-1
    • Muscarinic receptors
    • Nicotine
    • Nicotinic receptors

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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