Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

Wei Fan, Kate L J Ellacott, Ilia G. Halatchev, Kanji Takahashi, Pinxuan Yu, Roger D. Cone

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

Original languageEnglish (US)
Pages (from-to)335-336
Number of pages2
JournalNature Neuroscience
Volume7
Issue number4
DOIs
StatePublished - Apr 2004

Fingerprint

Melanocortins
Pro-Opiomelanocortin
Cholecystokinin
Brain Stem
Solitary Nucleus
Neurons
Receptor, Melanocortin, Type 4

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fan, W., Ellacott, K. L. J., Halatchev, I. G., Takahashi, K., Yu, P., & Cone, R. D. (2004). Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Nature Neuroscience, 7(4), 335-336. https://doi.org/10.1038/nn1214

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. / Fan, Wei; Ellacott, Kate L J; Halatchev, Ilia G.; Takahashi, Kanji; Yu, Pinxuan; Cone, Roger D.

In: Nature Neuroscience, Vol. 7, No. 4, 04.2004, p. 335-336.

Research output: Contribution to journalArticle

Fan, W, Ellacott, KLJ, Halatchev, IG, Takahashi, K, Yu, P & Cone, RD 2004, 'Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system', Nature Neuroscience, vol. 7, no. 4, pp. 335-336. https://doi.org/10.1038/nn1214
Fan, Wei ; Ellacott, Kate L J ; Halatchev, Ilia G. ; Takahashi, Kanji ; Yu, Pinxuan ; Cone, Roger D. / Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. In: Nature Neuroscience. 2004 ; Vol. 7, No. 4. pp. 335-336.
@article{6cc9be45753b4268904b0b6d9b5bbd29,
title = "Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system",
abstract = "Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.",
author = "Wei Fan and Ellacott, {Kate L J} and Halatchev, {Ilia G.} and Kanji Takahashi and Pinxuan Yu and Cone, {Roger D.}",
year = "2004",
month = "4",
doi = "10.1038/nn1214",
language = "English (US)",
volume = "7",
pages = "335--336",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

AU - Fan, Wei

AU - Ellacott, Kate L J

AU - Halatchev, Ilia G.

AU - Takahashi, Kanji

AU - Yu, Pinxuan

AU - Cone, Roger D.

PY - 2004/4

Y1 - 2004/4

N2 - Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

AB - Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

UR - http://www.scopus.com/inward/record.url?scp=1842560331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842560331&partnerID=8YFLogxK

U2 - 10.1038/nn1214

DO - 10.1038/nn1214

M3 - Article

VL - 7

SP - 335

EP - 336

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 4

ER -