Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation

Kelli M. Williams, Abby L. Dotson, Amber R. Otto, Jacob E. Kohlmeier, Stephen H. Benedict

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

With antigen stimulation, naïve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on naïve T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human naïve CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+CAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not.

Original languageEnglish (US)
Pages (from-to)418-427
Number of pages10
JournalCellular Immunology
Volume271
Issue number2
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • CD28
  • Costimulation
  • Foxp3
  • ICAM-1
  • Naïve T cell differentiation
  • Regulatory T cells

ASJC Scopus subject areas

  • Immunology

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