Abstract
With antigen stimulation, naïve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on naïve T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human naïve CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+CAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not.
Original language | English (US) |
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Pages (from-to) | 418-427 |
Number of pages | 10 |
Journal | Cellular Immunology |
Volume | 271 |
Issue number | 2 |
DOIs | |
State | Published - 2011 |
Externally published | Yes |
Keywords
- CD28
- Costimulation
- Foxp3
- ICAM-1
- Naïve T cell differentiation
- Regulatory T cells
ASJC Scopus subject areas
- Immunology