Choice of insufflating gas influences on wound metastasis

T. M. Farrell, R. E. Metreveli, A. B. Johnson, C. D. Smith, John Hunter

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Laparoscopic cancer surgery is limited by concerns about port-site metastasis. No study has definitively addressed the behavior and growth of tumor cells after the use of specific laparoscopic gases. Methods: In athymic rats, 10,000 colon cancer cells were injected intraperitoneally. The rats received either no pneumoperitoneum (pneumo) or pneumo (8 mmHg, 10 min) with carbon dioxide (CO2), nitrous oxide (N2O), or air. Two full-thickness incisions were made and closed in the upper abdomen of each animal. After 4 weeks, implants were identified grossly at necropsy, and invasiveness was scored according to penetration through the layers of the abdominal wall. Results: Rats receiving pneumo had more frequent implants (p <0.01) with deeper penetration (p <0.001) than rats not receiving pneumo. Implants were more common after air pneumo than after CO2 (p <0.05) or N2O (p = 0.07) pneumo, and were less penetrating after CO2 pneumo than after air (p <0.001) or N2O (p <0.05) pneumo. Conclusions: Carbon dioxide gas may limit the viability and invasiveness of free intraperitoneal tumor cells, as compared with air or N2O.

Original languageEnglish (US)
Pages (from-to)1047-1049
Number of pages3
JournalSurgical Endoscopy and Other Interventional Techniques
Volume14
Issue number11
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Pneumoperitoneum
Gases
Neoplasm Metastasis
Wounds and Injuries
Air
Carbon Dioxide
Nude Rats
Neoplasms
Nitrous Oxide
Abdominal Wall
Abdomen
Laparoscopy
Colonic Neoplasms
Growth

Keywords

  • Colon cancer
  • Gases
  • Implantation
  • Laparoscopy
  • Pneumoperitoneum
  • Port site

ASJC Scopus subject areas

  • Surgery

Cite this

Choice of insufflating gas influences on wound metastasis. / Farrell, T. M.; Metreveli, R. E.; Johnson, A. B.; Smith, C. D.; Hunter, John.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 14, No. 11, 2000, p. 1047-1049.

Research output: Contribution to journalArticle

Farrell, T. M. ; Metreveli, R. E. ; Johnson, A. B. ; Smith, C. D. ; Hunter, John. / Choice of insufflating gas influences on wound metastasis. In: Surgical Endoscopy and Other Interventional Techniques. 2000 ; Vol. 14, No. 11. pp. 1047-1049.
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AB - Background: Laparoscopic cancer surgery is limited by concerns about port-site metastasis. No study has definitively addressed the behavior and growth of tumor cells after the use of specific laparoscopic gases. Methods: In athymic rats, 10,000 colon cancer cells were injected intraperitoneally. The rats received either no pneumoperitoneum (pneumo) or pneumo (8 mmHg, 10 min) with carbon dioxide (CO2), nitrous oxide (N2O), or air. Two full-thickness incisions were made and closed in the upper abdomen of each animal. After 4 weeks, implants were identified grossly at necropsy, and invasiveness was scored according to penetration through the layers of the abdominal wall. Results: Rats receiving pneumo had more frequent implants (p <0.01) with deeper penetration (p <0.001) than rats not receiving pneumo. Implants were more common after air pneumo than after CO2 (p <0.05) or N2O (p = 0.07) pneumo, and were less penetrating after CO2 pneumo than after air (p <0.001) or N2O (p <0.05) pneumo. Conclusions: Carbon dioxide gas may limit the viability and invasiveness of free intraperitoneal tumor cells, as compared with air or N2O.

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