Chlorpyrifos exposure and respiratory health among adolescent agricultural workers

Callahan Catherine L, Batanony Manal Al, A. Ismail Ahmed, Rasou Gaafar Abdel, Hendy Olfat, Olson James R, Diane Rohlman, Bonner Matthew R

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Chlorpyrifos (CPF) is a commonly used organophosphate insecticide (OP). In adults, exposure to OPs has been inconsistently associated with reduced lung function. OP exposure and lung function has not been assessed in adolescents. The objective of this study was to assess CPF exposure and lung function among Egyptian adolescents. We conducted a 10-month study of male adolescent pesticide applicators (n = 38) and non-applicators of similar age (n = 24). Urinary 3,5,6-trichloro-2-pyridinol (TPCy), a CPF-specific metabolite, was analyzed in specimens collected throughout the study. Spirometry was performed twice after pesticide application: day 146, when TCPy levels were elevated and day 269,when TCPy levels were near baseline. Applicators had higher levels of TCPy (mean cumulative TCPy day 146 = 33,217.6; standard deviation (SD) = 49,179.3) than non-applicators (mean cumulative TCPy day 146 = 3290.8; SD = 3994.9). Compared with non-applicators, applicators had higher odds of reporting wheeze, odds ratio = 3.41(95% CI: 0.70; 17.41). Cumulative urinary TCPy was inversely associated with spirometric measurements at day 146, but not at day 269. Although generally non-significant, results were consistent with an inverse association between exposure to CPF and lung function.

Original languageEnglish (US)
Article numberA65
Pages (from-to)13117-13129
Number of pages13
JournalInternational Journal of Environmental Research and Public Health
Volume11
Issue number12
DOIs
StatePublished - Dec 16 2014

Fingerprint

Chlorpyrifos
Lung
Organophosphates
Insecticides
Pesticides
Spirometry
Odds Ratio
Adolescent Health
Farmers

Keywords

  • Adolescents
  • Chlorpyrifos
  • Lung function

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Catherine L, C., Manal Al, B., Ahmed, A. I., Gaafar Abdel, R., Olfat, H., James R, O., ... Matthew R, B. (2014). Chlorpyrifos exposure and respiratory health among adolescent agricultural workers. International Journal of Environmental Research and Public Health, 11(12), 13117-13129. [A65]. https://doi.org/10.3390/ijerph111213117

Chlorpyrifos exposure and respiratory health among adolescent agricultural workers. / Catherine L, Callahan; Manal Al, Batanony; Ahmed, A. Ismail; Gaafar Abdel, Rasou; Olfat, Hendy; James R, Olson; Rohlman, Diane; Matthew R, Bonner.

In: International Journal of Environmental Research and Public Health, Vol. 11, No. 12, A65, 16.12.2014, p. 13117-13129.

Research output: Contribution to journalArticle

Catherine L, C, Manal Al, B, Ahmed, AI, Gaafar Abdel, R, Olfat, H, James R, O, Rohlman, D & Matthew R, B 2014, 'Chlorpyrifos exposure and respiratory health among adolescent agricultural workers', International Journal of Environmental Research and Public Health, vol. 11, no. 12, A65, pp. 13117-13129. https://doi.org/10.3390/ijerph111213117
Catherine L, Callahan ; Manal Al, Batanony ; Ahmed, A. Ismail ; Gaafar Abdel, Rasou ; Olfat, Hendy ; James R, Olson ; Rohlman, Diane ; Matthew R, Bonner. / Chlorpyrifos exposure and respiratory health among adolescent agricultural workers. In: International Journal of Environmental Research and Public Health. 2014 ; Vol. 11, No. 12. pp. 13117-13129.
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