Chlorpromazine alters cochlear mechanics and amplification

In vivo evidence for a role of stiffness modulation in the organ of Corti

Jiefu Zheng, Niranjan Deo, Yuan Zou, Karl Grosh, Alfred Nuttall

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Although prestin-mediated outer hair cell (OHC) electromotility provides mechanical force for sound amplification in the mammalian cochlea, proper OHC stiffness is required to maintain normal electromotility and to transmit mechanical force to the basilar membrane (BM). To investigate the in vivo role of OHC stiffness in cochlear amplification, chlorpromazine (CPZ), an antipsychotic drug that alters OHC lateral wall biophysics, was infused into the cochleae in living guinea pigs. The effects of CPZ on cochlear amplification and OHC electromotility were observed by measuring the acoustically and electrically evoked BM motions. CPZ significantly reduced cochlear amplification as measured by a decline of the acoustically evoked BM motion near the best frequency (BF) accompanied by a loss of nonlinearity and broadened tuning. It also substantially reduced electrically evoked BM vibration near the BF and at frequencies above BF (

Original languageEnglish (US)
Pages (from-to)994-1004
Number of pages11
JournalJournal of Neurophysiology
Volume97
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Outer Auditory Hair Cells
Organ of Corti
Basilar Membrane
Cochlea
Chlorpromazine
Mechanics
Biophysics
Vibration
Cell Wall
Antipsychotic Agents
Guinea Pigs

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Chlorpromazine alters cochlear mechanics and amplification : In vivo evidence for a role of stiffness modulation in the organ of Corti. / Zheng, Jiefu; Deo, Niranjan; Zou, Yuan; Grosh, Karl; Nuttall, Alfred.

In: Journal of Neurophysiology, Vol. 97, No. 2, 02.2007, p. 994-1004.

Research output: Contribution to journalArticle

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