CHLORDIAZEPOXIDE EFFECTS ON ETHANOL SELF‐ADMINISTRATION: DEPENDENCE ON CONCURRENT CONDITIONS

Herman H. Samson, Kathleen A. Grant

    Research output: Contribution to journalArticle

    24 Scopus citations

    Abstract

    Experiments examined the effects of acute doses of chlordiazepoxide upon ethanol self‐administration in the rat. A concurrent‐schedule procedure was used that employed choice between ethanol (5%) and a second fluid (either water or a 1% sucrose solution). When ethanol and water were the available fluids, chlordiazepoxide at doses of 15 and 20 mg/kg reduced ethanol‐reinforced responding and intake, with a greater reduction occurring at the 20 mg/kg dose. However, when ethanol and sucrose were concurrently available, in many rats only the 20 mg/kg dose of chlordiazepoxide reduced ethanol‐reinforced responding. The differences in dose response function occurred in most animals without large changes in the baseline ethanol‐reinforced responding across the two concurrent conditions. Thus the dose‐effect curve relating chlordiazepoxide and ethanol self‐administration can be altered, dependent upon the nature of the concurrently available reinforcers. 1985 Society for the Experimental Analysis of Behavior

    Original languageEnglish (US)
    Pages (from-to)353-364
    Number of pages12
    JournalJournal of the experimental analysis of behavior
    Volume43
    Issue number3
    DOIs
    StatePublished - May 1985

    Keywords

    • chlordiazepoxide
    • concurrent schedules
    • economic analysis
    • ethanol self‐administration
    • fixed ratio
    • lever press
    • rate dependency
    • rats

    ASJC Scopus subject areas

    • Experimental and Cognitive Psychology
    • Behavioral Neuroscience

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