CHLORDIAZEPOXIDE EFFECTS ON ETHANOL SELF‐ADMINISTRATION: DEPENDENCE ON CONCURRENT CONDITIONS

Herman H. Samson, Kathleen A. Grant

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Experiments examined the effects of acute doses of chlordiazepoxide upon ethanol self‐administration in the rat. A concurrent‐schedule procedure was used that employed choice between ethanol (5%) and a second fluid (either water or a 1% sucrose solution). When ethanol and water were the available fluids, chlordiazepoxide at doses of 15 and 20 mg/kg reduced ethanol‐reinforced responding and intake, with a greater reduction occurring at the 20 mg/kg dose. However, when ethanol and sucrose were concurrently available, in many rats only the 20 mg/kg dose of chlordiazepoxide reduced ethanol‐reinforced responding. The differences in dose response function occurred in most animals without large changes in the baseline ethanol‐reinforced responding across the two concurrent conditions. Thus the dose‐effect curve relating chlordiazepoxide and ethanol self‐administration can be altered, dependent upon the nature of the concurrently available reinforcers. 1985 Society for the Experimental Analysis of Behavior

Original languageEnglish (US)
Pages (from-to)353-364
Number of pages12
JournalJournal of the experimental analysis of behavior
Volume43
Issue number3
DOIs
StatePublished - May 1985
Externally publishedYes

Keywords

  • chlordiazepoxide
  • concurrent schedules
  • economic analysis
  • ethanol self‐administration
  • fixed ratio
  • lever press
  • rate dependency
  • rats

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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