Chiral Synthesis and Enzymatic Resolution of (S)-(-)Piperazine-2-Carboxylic Acid Using Enzyme Alcalase

Guosheng Wu, Hua Zhao, Robert G. Luo, Dean Wei, Sanjay V. Malhotra

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Enantiomerically pure (S)-piperazine-2-carboxylic acid was synthesized by kinetic resolution of methyl-4-(tert-butyroxycarbonyl)-piperazine-2-carboxylate using a low cost enzyme alcalase.

Original languageEnglish (US)
Pages (from-to)343-345
Number of pages3
JournalEnantiomer
Volume6
Issue number6
StatePublished - 2001
Externally publishedYes

Keywords

  • (S)-piperazine-2-carboxylic acid
  • Chiral synthesis
  • Enzymatic resolution
  • Unnatural amino acid

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry

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