Khimernyǐ dreǐf v populiatsii éritrotsitov krovi u mysheǐ BALB/c----C57Bl/10 i BALB/c----B10.D2.

Translated title of the contribution: Chimeric drift in blood erythrocyte population in BALB/c----C57BL/10 and BALB----B10.D2 mice

Lev Fedorov, B. V. Koniukhov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Genotypic composition of the erythrocyte population of peripheral blood in 16 aggregation chimeras: BALB/c (H-2dd)----C57BL/10(H-2bb) and BALB/c(H-2dd)----B10.D2(H-2dd) was studied during 10 months. The proportion of cells of parental components was defined visually in the coat and by electrophoresis of allozyme variants at the Gpi-1 locus in blood. The similar increase of blood cells percentage was observed in blood of both types of chimeras with age. In chimeras the skin grafts of both parental types survive. Chimeric drift is not caused by H-2 haplotypes differences between cells of two strains or disturbance of immunological tolerance in the chimeric mice. We propose that chimeric drift results from interaction of hemopoietic cells of different strains in early stages of hemopoiesis.

Original languageUndefined
Pages (from-to)344-347
Number of pages4
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume106
Issue number9
StatePublished - Sep 1988
Externally publishedYes

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Blood
Erythrocytes
Population
Cellular Structures
Cell Communication
Haplotypes
Isoenzymes
Electrophoresis
Blood Cells
Grafts
Transplants
Skin
Agglomeration
Cells
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Khimernyǐ dreǐf v populiatsii éritrotsitov krovi u mysheǐ BALB/c----C57Bl/10 i BALB/c----B10.D2. / Fedorov, Lev; Koniukhov, B. V.

In: Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 106, No. 9, 09.1988, p. 344-347.

Research output: Contribution to journalArticle

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abstract = "Genotypic composition of the erythrocyte population of peripheral blood in 16 aggregation chimeras: BALB/c (H-2dd)----C57BL/10(H-2bb) and BALB/c(H-2dd)----B10.D2(H-2dd) was studied during 10 months. The proportion of cells of parental components was defined visually in the coat and by electrophoresis of allozyme variants at the Gpi-1 locus in blood. The similar increase of blood cells percentage was observed in blood of both types of chimeras with age. In chimeras the skin grafts of both parental types survive. Chimeric drift is not caused by H-2 haplotypes differences between cells of two strains or disturbance of immunological tolerance in the chimeric mice. We propose that chimeric drift results from interaction of hemopoietic cells of different strains in early stages of hemopoiesis.",
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