Childhood neglect and abuse as predictors of antidepressant response in adult depression

Jeni Johnstone, Suzanne E. Luty, Janet D. Carter, Roger T. Mulder, Christopher M A Frampton, Peter R. Joyce

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Childhood neglect and abuse are recognized as risk factors for depression, but are not often studied as predictors of treatment response in depression. Methods: Clinically depressed outpatients (n = 195) were asked about childhood experiences before beginning a randomized antidepressant trial with either fluoxetine or nortriptyline. Three treatment outcomes were measured: Adequate trial, six-week response and two months sustained recovery. Results: Patients reporting low paternal care (paternal neglect), as measured by the Parental Bonding Instrument (PBI), were less likely to complete an adequate six-week trial of medication. Patients who reported high maternal protection (maternal overprotection) on the PBI had poorer treatment response in the short-term at six weeks, and longer term, for two months of sustained recovery. However, abuse, whether sexual, physical, or psychological in nature, did not predict treatment response. Conclusions: The experience of having a neglectful father or an overprotective mother was more predictive of response to treatment for depression than abuse, suggesting that the quality of ongoing intra-familial relationships has a greater impact on treatment outcomes for depression than experiences of discrete abuse in childhood.

Original languageEnglish (US)
Pages (from-to)711-717
Number of pages7
JournalDepression and Anxiety
Volume26
Issue number8
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

Fingerprint

Antidepressive Agents
Depression
Mothers
Nortriptyline
Fluoxetine
Sex Offenses
Therapeutics
Fathers
Outpatients
Psychology
Object Attachment

Keywords

  • Abuse
  • Childhood adversity
  • Depression
  • Neglect
  • Parental Bonding Instrument (PBI)
  • Treatment predictors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Johnstone, J., Luty, S. E., Carter, J. D., Mulder, R. T., Frampton, C. M. A., & Joyce, P. R. (2009). Childhood neglect and abuse as predictors of antidepressant response in adult depression. Depression and Anxiety, 26(8), 711-717. https://doi.org/10.1002/da.20590

Childhood neglect and abuse as predictors of antidepressant response in adult depression. / Johnstone, Jeni; Luty, Suzanne E.; Carter, Janet D.; Mulder, Roger T.; Frampton, Christopher M A; Joyce, Peter R.

In: Depression and Anxiety, Vol. 26, No. 8, 01.08.2009, p. 711-717.

Research output: Contribution to journalArticle

Johnstone, J, Luty, SE, Carter, JD, Mulder, RT, Frampton, CMA & Joyce, PR 2009, 'Childhood neglect and abuse as predictors of antidepressant response in adult depression', Depression and Anxiety, vol. 26, no. 8, pp. 711-717. https://doi.org/10.1002/da.20590
Johnstone, Jeni ; Luty, Suzanne E. ; Carter, Janet D. ; Mulder, Roger T. ; Frampton, Christopher M A ; Joyce, Peter R. / Childhood neglect and abuse as predictors of antidepressant response in adult depression. In: Depression and Anxiety. 2009 ; Vol. 26, No. 8. pp. 711-717.
@article{303ece7869054cae89c1f4a398498286,
title = "Childhood neglect and abuse as predictors of antidepressant response in adult depression",
abstract = "Background: Childhood neglect and abuse are recognized as risk factors for depression, but are not often studied as predictors of treatment response in depression. Methods: Clinically depressed outpatients (n = 195) were asked about childhood experiences before beginning a randomized antidepressant trial with either fluoxetine or nortriptyline. Three treatment outcomes were measured: Adequate trial, six-week response and two months sustained recovery. Results: Patients reporting low paternal care (paternal neglect), as measured by the Parental Bonding Instrument (PBI), were less likely to complete an adequate six-week trial of medication. Patients who reported high maternal protection (maternal overprotection) on the PBI had poorer treatment response in the short-term at six weeks, and longer term, for two months of sustained recovery. However, abuse, whether sexual, physical, or psychological in nature, did not predict treatment response. Conclusions: The experience of having a neglectful father or an overprotective mother was more predictive of response to treatment for depression than abuse, suggesting that the quality of ongoing intra-familial relationships has a greater impact on treatment outcomes for depression than experiences of discrete abuse in childhood.",
keywords = "Abuse, Childhood adversity, Depression, Neglect, Parental Bonding Instrument (PBI), Treatment predictors",
author = "Jeni Johnstone and Luty, {Suzanne E.} and Carter, {Janet D.} and Mulder, {Roger T.} and Frampton, {Christopher M A} and Joyce, {Peter R.}",
year = "2009",
month = "8",
day = "1",
doi = "10.1002/da.20590",
language = "English (US)",
volume = "26",
pages = "711--717",
journal = "Depression and Anxiety",
issn = "1091-4269",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Childhood neglect and abuse as predictors of antidepressant response in adult depression

AU - Johnstone, Jeni

AU - Luty, Suzanne E.

AU - Carter, Janet D.

AU - Mulder, Roger T.

AU - Frampton, Christopher M A

AU - Joyce, Peter R.

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background: Childhood neglect and abuse are recognized as risk factors for depression, but are not often studied as predictors of treatment response in depression. Methods: Clinically depressed outpatients (n = 195) were asked about childhood experiences before beginning a randomized antidepressant trial with either fluoxetine or nortriptyline. Three treatment outcomes were measured: Adequate trial, six-week response and two months sustained recovery. Results: Patients reporting low paternal care (paternal neglect), as measured by the Parental Bonding Instrument (PBI), were less likely to complete an adequate six-week trial of medication. Patients who reported high maternal protection (maternal overprotection) on the PBI had poorer treatment response in the short-term at six weeks, and longer term, for two months of sustained recovery. However, abuse, whether sexual, physical, or psychological in nature, did not predict treatment response. Conclusions: The experience of having a neglectful father or an overprotective mother was more predictive of response to treatment for depression than abuse, suggesting that the quality of ongoing intra-familial relationships has a greater impact on treatment outcomes for depression than experiences of discrete abuse in childhood.

AB - Background: Childhood neglect and abuse are recognized as risk factors for depression, but are not often studied as predictors of treatment response in depression. Methods: Clinically depressed outpatients (n = 195) were asked about childhood experiences before beginning a randomized antidepressant trial with either fluoxetine or nortriptyline. Three treatment outcomes were measured: Adequate trial, six-week response and two months sustained recovery. Results: Patients reporting low paternal care (paternal neglect), as measured by the Parental Bonding Instrument (PBI), were less likely to complete an adequate six-week trial of medication. Patients who reported high maternal protection (maternal overprotection) on the PBI had poorer treatment response in the short-term at six weeks, and longer term, for two months of sustained recovery. However, abuse, whether sexual, physical, or psychological in nature, did not predict treatment response. Conclusions: The experience of having a neglectful father or an overprotective mother was more predictive of response to treatment for depression than abuse, suggesting that the quality of ongoing intra-familial relationships has a greater impact on treatment outcomes for depression than experiences of discrete abuse in childhood.

KW - Abuse

KW - Childhood adversity

KW - Depression

KW - Neglect

KW - Parental Bonding Instrument (PBI)

KW - Treatment predictors

UR - http://www.scopus.com/inward/record.url?scp=68149147579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68149147579&partnerID=8YFLogxK

U2 - 10.1002/da.20590

DO - 10.1002/da.20590

M3 - Article

C2 - 19544315

AN - SCOPUS:68149147579

VL - 26

SP - 711

EP - 717

JO - Depression and Anxiety

JF - Depression and Anxiety

SN - 1091-4269

IS - 8

ER -