Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases

Edward Neuwelt, Suellen A. Dahlborg

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Clinical experience in seven patients with systemic malignancies (breast, lung and testicular) metastatic to the central nervous system treated with chemotherapy given in association with reversible osmotic blood-brain barrier modification is reviewed. A combination chemotherapy regimen including intra-arterial methotrexate, intravenous cytoxan and oral procarbazine in conjunction with intra-arterial mannitol infusions was successfully carried out with minimal toxicity. The results in these patients demonstrate some therapeutic efficacy to the increased drug delivery achieved with this technique. Although suggestive, additional studies will be required to confirm that barrier modification is a key parameter in such efficacy.

Original languageEnglish (US)
Pages (from-to)195-207
Number of pages13
JournalJournal of Neuro-Oncology
Volume4
Issue number3
DOIs
StatePublished - Sep 1987

Fingerprint

Blood-Brain Barrier
Neoplasm Metastasis
Procarbazine
Drug Therapy
Intra Arterial Infusions
Brain
Mannitol
Combination Drug Therapy
Methotrexate
Cyclophosphamide
Breast
Central Nervous System
Lung
Pharmaceutical Preparations
Neoplasms
Therapeutics

Keywords

  • blood-brain barrier
  • chemotherapy
  • CNS metastases

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases. / Neuwelt, Edward; Dahlborg, Suellen A.

In: Journal of Neuro-Oncology, Vol. 4, No. 3, 09.1987, p. 195-207.

Research output: Contribution to journalArticle

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