Chemistry and biology of DNA containing 1,N²-deoxyguanosine adducts of the α,β-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal

Medicine & Life Sciences

• 2-butenal 100%
• Acrolein 80%
• 4-hydroxy-2-nonenal 73%
• Aldehydes 66%
• DNA 30%
• DNA-Directed DNA Polymerase 15%
• Escherichia coli 14%
• Cyclization 10%
• Schiff Bases 10%
• Peptides 8%
• Homologous Recombination 7%
• Mutation 7%
• Site-Directed Mutagenesis 7%
• Amines 7%
• Lipid Peroxidation 6%
• DNA Repair 6%
• Rodentia 5%
• Nucleotides 5%
• Oxidative Stress 5%
• In Vitro Techniques 3%
• Proteins 2%

Chemical Compounds

• Crotonaldehyde 74%
• Acrolein 65%
• Adduct 39%
• Aldehyde 38%
• Chemistry 32%
• Mammalian Cell 21%
• Mutation 11%
• Nucleotide 11%
• Enal 11%
• Peptide 8%
• Michael Addition 7%
• Oxidative Stress 6%
• Ring Opening Reaction 6%
• Schiff Base 5%
• Cyclization Reaction 5%
• Lipid 4%
• Modification 3%
• Mixture 3%