Chemical dissolution of retained ductal stone(s) is recommended when mechanical extraction through the formed T-tube tract fails. Sodium cholate solution has been most widely used for infusion, and two-thirds of patients can be successfully treated. A new agent, the medium chain glyceride mono-octanoin, is more potent in vitro and the results of early clinical trials are encouraging. The use of oral longterm chenodeoxycholic acid for treatment of nonobstructing asymptomatic ductal stones has been successful in 50% of a small number of patients.
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