Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging

Kai Bao; Khaled A. Nasr; Hoon Hyun; Jeong Heon Lee; Julien Gravier; Summer L. Gibbs; Hak Soo Choi

doi:10.7150/thno.11222

Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging

Kai Bao, Khaled A. Nasr, Hoon Hyun, Jeong Heon Lee, Julien Gravier, Summer L. Gibbs, Hak Soo Choi

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared their bone targeting efficiency, biodistribution, and blood clearance. Since the targeting moiety, PAM, is highly negatively charged but small, the overall in vivo bone targeting and biodistribution were mediated by the physicochemical properties of conjugated fluorophores.

Original language	English (US)
Pages (from-to)	609-617
Number of pages	9
Journal	Theranostics
Volume	5
Issue number	6
DOIs	https://doi.org/10.7150/thno.11222
State	Published - 2015

Keywords

Bone targeting
Charge and hydrophobicity
Microcalcification
Near-infrared fluorophores
Zwitterionic fluorophores

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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10.7150/thno.11222

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abstract = "Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared their bone targeting efficiency, biodistribution, and blood clearance. Since the targeting moiety, PAM, is highly negatively charged but small, the overall in vivo bone targeting and biodistribution were mediated by the physicochemical properties of conjugated fluorophores.",

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T1 - Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging

AU - Bao, Kai

AU - Nasr, Khaled A.

AU - Hyun, Hoon

AU - Lee, Jeong Heon

AU - Gravier, Julien

AU - Gibbs, Summer L.

AU - Choi, Hak Soo

PY - 2015

Y1 - 2015

N2 - Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared their bone targeting efficiency, biodistribution, and blood clearance. Since the targeting moiety, PAM, is highly negatively charged but small, the overall in vivo bone targeting and biodistribution were mediated by the physicochemical properties of conjugated fluorophores.

AB - Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared their bone targeting efficiency, biodistribution, and blood clearance. Since the targeting moiety, PAM, is highly negatively charged but small, the overall in vivo bone targeting and biodistribution were mediated by the physicochemical properties of conjugated fluorophores.

KW - Bone targeting

KW - Charge and hydrophobicity

KW - Microcalcification

KW - Near-infrared fluorophores

KW - Zwitterionic fluorophores

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Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging

Abstract

Keywords

ASJC Scopus subject areas

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