Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators

Diane Rohlman, Ahmed A. Ismail, Gaafar Abdel-Rasoul, Michael Lasarev, Olfat Hendy, James R. Olson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Children and adolescents may have occupational exposure to pesticides. Although previous studies examining prenatal pesticide exposure have identified neurobehavioral deficits in children, there are limited studies examining the impact of occupational exposure in children. The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls. A neurobehavioral test battery, consisting of 14 tests, was used to assess a broad range of functions. Applicators performed worse than controls on the majority of tests. Principal component analysis was used to reduce the number of outcome variables and two components, focused on reasoning-short-term memory and attention-executive functioning, showed significant deficits in applicators compared to non-applicators. Elevated metabolite levels were found in the applicators compared to the non-applicators, confirming CPF exposure in the applicators. Although this study is limited by a small sample size, it provides preliminary evidence of moderate CPF exposures, decreased blood ChE in some applicators and decreased neurobehavioral performance in an adolescent working population.

Original languageEnglish (US)
Pages (from-to)845-855
Number of pages11
JournalMetabolic Brain Disease
Volume29
Issue number3
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

Fingerprint

Chlorpyrifos
Applicators
Pesticides
Cholinesterases
Occupational Exposure
Metabolites
Blood
Principal Component Analysis
Short-Term Memory
Sample Size
Principal component analysis
Population
Data storage equipment

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Rohlman, D., Ismail, A. A., Abdel-Rasoul, G., Lasarev, M., Hendy, O., & Olson, J. R. (2014). Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators. Metabolic Brain Disease, 29(3), 845-855. https://doi.org/10.1007/s11011-014-9565-9

Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators. / Rohlman, Diane; Ismail, Ahmed A.; Abdel-Rasoul, Gaafar; Lasarev, Michael; Hendy, Olfat; Olson, James R.

In: Metabolic Brain Disease, Vol. 29, No. 3, 01.09.2014, p. 845-855.

Research output: Contribution to journalArticle

Rohlman, D, Ismail, AA, Abdel-Rasoul, G, Lasarev, M, Hendy, O & Olson, JR 2014, 'Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators', Metabolic Brain Disease, vol. 29, no. 3, pp. 845-855. https://doi.org/10.1007/s11011-014-9565-9
Rohlman, Diane ; Ismail, Ahmed A. ; Abdel-Rasoul, Gaafar ; Lasarev, Michael ; Hendy, Olfat ; Olson, James R. / Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators. In: Metabolic Brain Disease. 2014 ; Vol. 29, No. 3. pp. 845-855.
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