Characterization of tissue histopathology via predictive sparse decomposition and spatial pyramid matching.

Hang Chang, Nandita Nayak, Paul Spellman, Bahram Parvin

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Citations (Scopus)

Abstract

Image-based classification of tissue histology, in terms of different components (e.g., subtypes of aberrant phenotypic signatures), provides a set of indices for tumor composition. Subsequently, integration of these indices in whole slide images (WSI), from a large cohort, can provide predictive models of the clinical outcome. However, the performance of the existing histology-based classification techniques is hindered as a result of large technical and biological variations that are always present in a large cohort. In this paper, we propose an algorithm for classification of tissue histology based on predictive sparse decomposition (PSD) and spatial pyramid matching (SPM), which utilize sparse tissue morphometric signatures at various locations and scales. The method has been evaluated on two distinct datasets of different tumor types collected from The Cancer Genome Atlas (TCGA). The novelties of our approach are: (i) extensibility to different tumor types; (ii) robustness in the presence of wide technical and biological variations; and (iii) scalability with varying training sample size.

Original languageEnglish (US)
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages91-98
Number of pages8
Volume16
EditionPt 2
StatePublished - 2013

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Histology
Neoplasms
Atlases
Sample Size
Genome
Datasets

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chang, H., Nayak, N., Spellman, P., & Parvin, B. (2013). Characterization of tissue histopathology via predictive sparse decomposition and spatial pyramid matching. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention (Pt 2 ed., Vol. 16, pp. 91-98)

Characterization of tissue histopathology via predictive sparse decomposition and spatial pyramid matching. / Chang, Hang; Nayak, Nandita; Spellman, Paul; Parvin, Bahram.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 16 Pt 2. ed. 2013. p. 91-98.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chang, H, Nayak, N, Spellman, P & Parvin, B 2013, Characterization of tissue histopathology via predictive sparse decomposition and spatial pyramid matching. in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 2 edn, vol. 16, pp. 91-98.
Chang H, Nayak N, Spellman P, Parvin B. Characterization of tissue histopathology via predictive sparse decomposition and spatial pyramid matching. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 2 ed. Vol. 16. 2013. p. 91-98
Chang, Hang ; Nayak, Nandita ; Spellman, Paul ; Parvin, Bahram. / Characterization of tissue histopathology via predictive sparse decomposition and spatial pyramid matching. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 16 Pt 2. ed. 2013. pp. 91-98
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