Characterization of Thyroid Abnormalities in a Large Cohort of Children with Down Syndrome

Melinda J. Pierce, Stephen Lafranchi, Joseph Pinter

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/Aims: Thyroid disease is a common comorbidity in individuals with Down syndrome (DS), but historical studies have multiple limitations. We assessed thyroid abnormalities in a large cohort of children with DS. Methods: Retrospective records review from a single institution. Calculated prevalence of common thyroid abnormalities and associations with common comorbidities. Results: Among 508 patients, 120 (24%) had a thyroid-related diagnosis, the majority having elevated thyrotropin treated with levothyroxine. A Kaplan-Meier estimate projects that 50% have thyroid disorder by adulthood, with 20% of hypothyroidism diagnosed before the age of 6 months. When tested, approximately 50% had positive antithyroid antibodies, though this rate was 100% in overt hypothyroidism. There was no association between congenital or acquired hypothyroidism and common comorbidities. Conclusion: Thyroid disease in DS is more common and occurs earlier than in the general population, and is often transient. Thyroid disease is unrelated to gender, obesity, or other comorbidities. Apart from overt hypothyroidism, much of hypothyroidism in DS appears unrelated to autoimmunity; we recommend checking of antithyroid antibodies only in select cases. An additional screen for thyroid disease between the newborn screen and the 6-month well-child visit will detect early cases of hypothyroidism who passed their newborn screen.

Original languageEnglish (US)
Pages (from-to)170-178
Number of pages9
JournalHormone Research in Paediatrics
DOIs
StateAccepted/In press - Mar 3 2017

Fingerprint

Down Syndrome
Hypothyroidism
Thyroid Gland
Thyroid Diseases
Comorbidity
Newborn Infant
Antibodies
Kaplan-Meier Estimate
Thyrotropin
Autoimmunity
Thyroxine
Obesity
Population

Keywords

  • Congenital heart malformation
  • Congenital hypothyroidism
  • Down syndrome
  • Screening
  • Thyroid diseases

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Characterization of Thyroid Abnormalities in a Large Cohort of Children with Down Syndrome. / Pierce, Melinda J.; Lafranchi, Stephen; Pinter, Joseph.

In: Hormone Research in Paediatrics, 03.03.2017, p. 170-178.

Research output: Contribution to journalArticle

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