Abstract
Synthetic envelope peptides of a simian retrovirus (SRV-2) were used to define both T- and B-cell epitopes of the envelope protein. The SRV-2 peptide 100-106 specifically blocks rhesus anti-SRV-2 neutralizing antibody activity, and a peptide 100-106 keyhole limpet hemocyanin conjugate induces a strong antipeptide antibody response. SRV-2 peptide 100-106 and 233-249 induces good T-cell proliferation of murine spleen cells immunized with the SRV-2 virus. Thus, SRV-2 envelope peptide 100-106 represents both a T- and B-cell epitope, and peptide 233-249 a T-cell epitope.
Original language | English (US) |
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Pages (from-to) | 177-181 |
Number of pages | 5 |
Journal | Journal of medical primatology |
Volume | 20 |
Issue number | 4 |
State | Published - Jun 1991 |
ASJC Scopus subject areas
- Animal Science and Zoology
- General Veterinary