Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein.

A. Malley, L. Werner, E. Benjamini, C. Y. Leung, J. Torres, N. Pangares, S. Shiigi, M. Axthelm

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations

    Abstract

    Synthetic envelope peptides of a simian retrovirus (SRV-2) were used to define both T- and B-cell epitopes of the envelope protein. The SRV-2 peptide 100-106 specifically blocks rhesus anti-SRV-2 neutralizing antibody activity, and a peptide 100-106 keyhole limpet hemocyanin conjugate induces a strong antipeptide antibody response. SRV-2 peptide 100-106 and 233-249 induces good T-cell proliferation of murine spleen cells immunized with the SRV-2 virus. Thus, SRV-2 envelope peptide 100-106 represents both a T- and B-cell epitope, and peptide 233-249 a T-cell epitope.

    Original languageEnglish (US)
    Pages (from-to)177-181
    Number of pages5
    JournalJournal of medical primatology
    Volume20
    Issue number4
    StatePublished - Jun 1991

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

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