Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein.

A. Malley, L. Werner, E. Benjamini, C. Y. Leung, J. Torres, N. Pangares, S. Shiigi, Michael Axthelm

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Synthetic envelope peptides of a simian retrovirus (SRV-2) were used to define both T- and B-cell epitopes of the envelope protein. The SRV-2 peptide 100-106 specifically blocks rhesus anti-SRV-2 neutralizing antibody activity, and a peptide 100-106 keyhole limpet hemocyanin conjugate induces a strong antipeptide antibody response. SRV-2 peptide 100-106 and 233-249 induces good T-cell proliferation of murine spleen cells immunized with the SRV-2 virus. Thus, SRV-2 envelope peptide 100-106 represents both a T- and B-cell epitope, and peptide 233-249 a T-cell epitope.

    Original languageEnglish (US)
    Pages (from-to)177-181
    Number of pages5
    JournalJournal of Medical Primatology
    Volume20
    Issue number4
    StatePublished - Jun 1991

    Fingerprint

    Mason-Pfizer monkey virus
    B-Lymphocyte Epitopes
    T-Lymphocyte Epitopes
    epitopes
    B-lymphocytes
    T-lymphocytes
    peptides
    Proteins
    proteins
    Peptides
    splenocytes
    neutralizing antibodies
    Neutralizing Antibodies
    cell proliferation
    Antibody Formation
    Spleen
    Cell Proliferation
    viruses
    antibodies
    Viruses

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

    Cite this

    Malley, A., Werner, L., Benjamini, E., Leung, C. Y., Torres, J., Pangares, N., ... Axthelm, M. (1991). Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein. Journal of Medical Primatology, 20(4), 177-181.

    Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein. / Malley, A.; Werner, L.; Benjamini, E.; Leung, C. Y.; Torres, J.; Pangares, N.; Shiigi, S.; Axthelm, Michael.

    In: Journal of Medical Primatology, Vol. 20, No. 4, 06.1991, p. 177-181.

    Research output: Contribution to journalArticle

    Malley, A, Werner, L, Benjamini, E, Leung, CY, Torres, J, Pangares, N, Shiigi, S & Axthelm, M 1991, 'Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein.', Journal of Medical Primatology, vol. 20, no. 4, pp. 177-181.
    Malley A, Werner L, Benjamini E, Leung CY, Torres J, Pangares N et al. Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein. Journal of Medical Primatology. 1991 Jun;20(4):177-181.
    Malley, A. ; Werner, L. ; Benjamini, E. ; Leung, C. Y. ; Torres, J. ; Pangares, N. ; Shiigi, S. ; Axthelm, Michael. / Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein. In: Journal of Medical Primatology. 1991 ; Vol. 20, No. 4. pp. 177-181.
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    AU - Torres, J.

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    AU - Shiigi, S.

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